2021
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study
Murray K, Lin Y, Makary MM, Whang PG, Geha P. Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study. Molecular Pain 2021, 17: 1744806921990938. PMID: 33567986, PMCID: PMC7883154, DOI: 10.1177/1744806921990938.Peer-Reviewed Original ResearchConceptsChronic low back painOpioid analgesicsCLBP patientsPain patientsChronic low back pain patientsLow back pain patientsBrain structuresOpioid analgesic treatmentBack pain patientsClasses of medicationsChronic pain patientsLow back painLong-term riskAltered brain structureSub-cortical areasOverall significant decreaseEvidence of misuseAnalgesic treatmentChronic treatmentBack painFunctional brain imagingLimbic areasUnmedicated patientsHealthy controlsNucleus accumbens
2020
Evidence-Based Recommendations for Spine Surgery.
Fisher CG, Vaccaro AR, Patel AA, Whang PG, Thomas KC, Chi J, Mulpuri K, Prasad SK. Evidence-Based Recommendations for Spine Surgery. Spine 2020, 45: 851-859. PMID: 32355150, DOI: 10.1097/brs.0000000000003512.Peer-Reviewed Original ResearchConceptsSpine surgeryDecompression surgeryLumbar decompression surgerySpinal decompression surgeryPost-operative MRISagittal spinopelvic alignmentEvidence-based recommendationsLumbar disc arthroplastyLumbar surgeryPrognostic factorsTranexamic acidOsteoporotic patientsDisc arthroplastySpinopelvic alignmentSurgeryClinical practiceComparative effectivenessPatientsArthroplastyRecommendationsFusion supportMRILoss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2017
Predictors of Outcome in Conservative and Minimally Invasive Surgical Management of Pain Originating From the Sacroiliac Joint
Dengler J, Duhon B, Whang P, Frank C, Glaser J, Sturesson B, Garfin S, Cher D, Rendahl A, Polly D. Predictors of Outcome in Conservative and Minimally Invasive Surgical Management of Pain Originating From the Sacroiliac Joint. Spine 2017, 42: 1664-1673. PMID: 28350586, PMCID: PMC5636200, DOI: 10.1097/brs.0000000000002169.Peer-Reviewed Original ResearchConceptsOswestry Disability IndexPredictors of outcomeSIJ fusionVisual analog scaleInvasive surgical managementSacroiliac jointSIJ painTreatment outcomesConservative managementProspective trialSurgical managementSingle-arm prospective trialInvasive SIJ fusionLonger pain durationLower patient ageInvasive surgical treatmentIndividual patient dataPatient-level analysisTriangular titanium implantsBetter treatment outcomesAnalysis of predictorsRandom-effects modelMultivariate regression analysisTrial sample sizeNonopioid users
2015
Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs Nonsurgical Management for Sacroiliac Joint Dysfunction: 12-Month Outcomes
Polly DW, Cher DJ, Wine KD, Whang PG, Frank CJ, Harvey CF, Lockstadt H, Glaser JA, Limoni RP, Sembrano JN. Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs Nonsurgical Management for Sacroiliac Joint Dysfunction: 12-Month Outcomes. Neurosurgery 2015, 77: 674-691. PMID: 26291338, PMCID: PMC4605280, DOI: 10.1227/neu.0000000000000988.Peer-Reviewed Original ResearchConceptsTriangular titanium implantsQuality of lifeSacroiliac joint dysfunctionSurgical groupNonsurgical managementSIJ dysfunctionSIJ fusionJoint dysfunctionOswestry Disability Index improvementSix-month success rateInvasive Sacroiliac Joint FusionChronic SIJ dysfunctionInvasive SIJ fusionNonsurgical management groupsOswestry Disability IndexSacroiliac joint fusionLow back painRandomized Controlled TrialsLevel 1 studiesSuccess rateTitanium implantsDegenerative sacroiliitisSIJ disruptionDisability IndexSIJ pain
2013
Comparison of Axial and Anterior Interbody Fusions of the L5–S1 Segment
Whang PG, Sasso RC, Patel VV, Ali RM, Fischgrund JS. Comparison of Axial and Anterior Interbody Fusions of the L5–S1 Segment. Clinical Spine Surgery A Spine Publication 2013, 26: 437-443. PMID: 24196923, DOI: 10.1097/bsd.0b013e318292aad7.Peer-Reviewed Original ResearchConceptsAnterior lumbar interbody fusionAdverse eventsInterbody fusionPosterior fixationDevice-related adverse eventsL5-S1 interbody fusionL5-S1 disc spaceAnterior interbody fusionAnterior retroperitoneal approachSerious intraoperative complicationsAnterior column supportDifferent surgical approachesLumbar interbody fusionRadiographic fusion rateL5-S1 segmentSupplemental posterior fixationAxiaLIF techniqueHospital chartsIntraoperative complicationsMulticenter reviewRadiographic successRetroperitoneal approachArthrodesis ratesPresacral spaceProcedural data
2011
The Effects of Three Different Types of Orthoses on the Range of Motion of the Lumbar Spine During 15 Activities of Daily Living
Jegede KA, Miller CP, Bible JE, Whang PG, Grauer JN. The Effects of Three Different Types of Orthoses on the Range of Motion of the Lumbar Spine During 15 Activities of Daily Living. Spine 2011, 36: 2346-2353. PMID: 21358469, DOI: 10.1097/brs.0b013e31820921a5.Peer-Reviewed Original ResearchThe Development and Evaluation of the Subaxial Injury Classification Scoring System for Cervical Spine Trauma
Whang PG, Patel AA, Vaccaro AR. The Development and Evaluation of the Subaxial Injury Classification Scoring System for Cervical Spine Trauma. Clinical Orthopaedics And Related Research® 2011, 469: 723-731. PMID: 20857247, PMCID: PMC3032869, DOI: 10.1007/s11999-010-1576-1.Peer-Reviewed Original Research
2010
The Effect of Rigid Cervical Collar Height on Full, Active, and Functional Range of Motion During Fifteen Activities of Daily Living
Miller CP, Bible JE, Jegede KA, Whang PG, Grauer JN. The Effect of Rigid Cervical Collar Height on Full, Active, and Functional Range of Motion During Fifteen Activities of Daily Living. Spine 2010, 35: e1546-e1552. PMID: 21116218, DOI: 10.1097/brs.0b013e3181cf6f73.Peer-Reviewed Original ResearchConceptsHard cervical collarFunctional ROMDaily livingCervical collarActive ROMCoronal planeFull active ROMSagittal planeSkin-related issuesDifferent collar heightsCervical ROMHard collarClinical significanceCollar heightBACKGROUND DATAActive rangeNeck extensionClinical settingNeutral positionROM measurementsFunctional rangeCorresponding decreaseFunctional positionBiomechanical experimentsROMSoft and Rigid Collars Provide Similar Restriction in Cervical Range of Motion During Fifteen Activities of Daily Living
Miller CP, Bible JE, Jegede KA, Whang PG, Grauer JN. Soft and Rigid Collars Provide Similar Restriction in Cervical Range of Motion During Fifteen Activities of Daily Living. Spine 2010, 35: 1271-1278. PMID: 20512025, DOI: 10.1097/brs.0b013e3181c0ddad.Peer-Reviewed Original ResearchConceptsSoft collarRigid collarActive ROMCervical spineCervical motionRigid orthosisCervical collarFunctional ROMDaily livingProspective cohort studyPaucity of dataCohort studyCervical rangePostoperative bracingInternal fixationBACKGROUND DATACertain injuriesSurgical proceduresRigid braceFlexion/extensionADLRelative efficacyFunctional tasksCervical devicesROM measurementsNormal Functional Range of Motion of the Lumbar Spine During 15 Activities of Daily Living
Bible JE, Biswas D, Miller CP, Whang PG, Grauer JN. Normal Functional Range of Motion of the Lumbar Spine During 15 Activities of Daily Living. Clinical Spine Surgery A Spine Publication 2010, 23: 106-112. PMID: 20065869, DOI: 10.1097/bsd.0b013e3181981823.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultBiomechanical PhenomenaElectrodiagnosisFemaleHumansIntervertebral DiscLumbar VertebraeMaleMiddle AgedMovementOutcome Assessment, Health CareProspective StudiesRange of Motion, ArticularReference ValuesTask Performance and AnalysisYoung AdultZygapophyseal JointConceptsFull active ROMLumbar spineAsymptomatic subjectsActive ROMFunctional ROMDaily livingFlexion/extensionProspective clinical studyLateral bending radiographsDynamic flexion/extensionNormal functional rangeIntraclass correlation coefficientLumbar ROMPreoperative impairmentPostsurgical outcomesClinical studiesBACKGROUND DATALumbar rangeLumbar motionSpinal ROMConsecutive daysADLRadiographic measurementsSpineROM valuesNormal Functional Range of Motion of the Cervical Spine During 15 Activities of Daily Living
Bible JE, Biswas D, Miller CP, Whang PG, Grauer JN. Normal Functional Range of Motion of the Cervical Spine During 15 Activities of Daily Living. Clinical Spine Surgery A Spine Publication 2010, 23: 15-21. PMID: 20051924, DOI: 10.1097/bsd.0b013e3181981632.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAgedAnthropometryArthrographyArthrometry, ArticularBiomechanical PhenomenaCervical VertebraeCineradiographyFemaleHead MovementsHumansIntervertebral DiscMaleMiddle AgedMovementNeck MusclesProspective StudiesRange of Motion, ArticularReference ValuesYoung AdultZygapophyseal JointConceptsFull active ROMAsymptomatic subjectsCervical spineCervical ROMActive ROMFunctional ROMDaily livingFlexion/extensionProspective clinical studyLateral bending radiographsNormal cervical rangeDynamic flexion/extensionNormal functional rangeIntraclass correlation coefficientPreoperative impairmentCervical rangePostsurgical outcomesCervical motionClinical studiesBACKGROUND DATASpinal ROMConsecutive daysRadiographic measurementsADLGreater ROM
2009
The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Whang PG, Goldberg G, Lawrence JP, Hong J, Harrop JS, Anderson DG, Albert TJ, Vaccaro AR. The Management of Spinal Injuries in Patients With Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis. Clinical Spine Surgery A Spine Publication 2009, 22: 77-85. PMID: 19342927, DOI: 10.1097/bsd.0b013e3181679bcb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComorbidityDisability EvaluationFemaleHumansHyperostosis, Diffuse Idiopathic SkeletalMaleMiddle AgedMortalityNeurosurgical ProceduresOutcome Assessment, Health CarePostoperative ComplicationsRadiographyRetrospective StudiesSpinal Cord CompressionSpinal FracturesSpinal InjuriesSpineSpondylitis, AnkylosingTreatment OutcomeConceptsDiffuse idiopathic skeletal hyperostosisIdiopathic skeletal hyperostosisSpinal injuryDISH patientsNeurologic deficitsClinical outcomesAS patientsSkeletal hyperostosisAmerican Spinal Injury Association Impairment ScaleHalo-vest orthosisOverall complication rateHalo-vest immobilizationAppropriate imaging studiesSpinal cord injurySubaxial cervical spineOdom's criteriaNonoperative treatmentComplication rateNeurologic injuryNeurologic statusASIA ARetrospective reviewOperative managementCord injurySingle institutionThoracolumbar spine trauma classification: the Thoracolumbar Injury Classification and Severity Score system and case examples.
Patel AA, Dailey A, Brodke DS, Daubs M, Harrop J, Whang PG, Vaccaro AR, _ _. Thoracolumbar spine trauma classification: the Thoracolumbar Injury Classification and Severity Score system and case examples. Journal Of Neurosurgery Spine 2009, 10: 201-6. PMID: 19320578, DOI: 10.3171/2008.12.spine08388.Peer-Reviewed Original Research
2008
Pseudarthrosis following lumbar interbody fusion using bone morphogenetic protein-2: intraoperative and histopathologic findings.
Whang PG, O'Hara BJ, Ratliff J, Sharan A, Brown Z, Vaccaro AR. Pseudarthrosis following lumbar interbody fusion using bone morphogenetic protein-2: intraoperative and histopathologic findings. Orthopedics 2008, 31 PMID: 19226004, DOI: 10.3928/01477447-20110525-20.Peer-Reviewed Original ResearchFinancial Incentives for Lumbar Surgery: A Critical Analysis of Physician Reimbursement for Decompression and Fusion Procedures
Whang PG, Lim MR, Sasso RC, Skelton A, Brown ZB, Anderson D, Albert TJ, Hilibrand AS, Vaccaro AR. Financial Incentives for Lumbar Surgery: A Critical Analysis of Physician Reimbursement for Decompression and Fusion Procedures. Clinical Spine Surgery A Spine Publication 2008, 21: 381-386. PMID: 18679090, DOI: 10.1097/bsd.0b013e31814d4e1b.Peer-Reviewed Original ResearchConceptsInstrumented fusion proceduresFusion proceduresIsolated decompressionAutogenous iliac crest boneSingle-level decompressionIliac crest boneLumbar degenerative conditionsLumbar decompressionLumbar surgeryPostoperative visitDecompression groupSingle surgeonConsecutive seriesOffice chartsOperative reportsPosterolateral fusionSurgical timeTotal clinical timeCrest boneLumbar degenerationSpinal fusionBACKGROUND DATALumbar arthrodesisType of operationSpine surgeons
2007
Acute cervical osteomyelitis and prevertebral abscess after routine tonsillectomy
Patel AA, Madigan L, Poelstra KA, Whang PG, Vaccaro AR, Harrop JS. Acute cervical osteomyelitis and prevertebral abscess after routine tonsillectomy. The Spine Journal 2007, 8: 827-830. PMID: 17697802, DOI: 10.1016/j.spinee.2007.04.019.Peer-Reviewed Original ResearchConceptsCervical osteomyelitisRoutine tonsillectomyPrevertebral abscessCase reportSpine literatureIntravenous antibiotic therapyDeep cervical infectionSigns of infectionPosterior surgical stabilizationIntravenous antibioticsOperative debridementCervical infectionClinical suspicionFatal complicationAntibiotic therapySignificant morbiditySurgical stabilizationAbscess formationPatient presentingSevere infectionsSuccessful treatmentSurgical proceduresRadiographic dataHigh indexTonsillectomyThe safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study
Vaccaro AR, Whang PG, Patel T, Phillips FM, Anderson DG, Albert TJ, Hilibrand AS, Brower RS, Kurd MF, Appannagari A, Patel M, Fischgrund JS. The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study. The Spine Journal 2007, 8: 457-465. PMID: 17588821, DOI: 10.1016/j.spinee.2007.03.012.Peer-Reviewed Original ResearchConceptsOP-1 PuttyUninstrumented fusionIliac crest autograftDegenerative spondylolisthesisOverall success rateAutograft patientsX-ray filmsAdverse eventsDecompressive laminectomyCrest autograftAutogenous boneShort Form Health Survey scoresForm Health Survey scoresBone graft substituteAutogenous iliac crest bone graftIliac crest bone graftPatient-reported outcome measuresPilot studyIntermediate-term efficacyOswestry Disability IndexPreoperative Oswestry scoreHealth Survey scoresPrimary efficacy endpointSF-36 scoresSymptomatic spinal stenosis