2013
Complications Associated With the Use of the Recombinant Human Bone Morphogenetic Proteins for Posterior Interbody Fusions of the Lumbar Spine
Chrastil J, Low JB, Whang PG, Patel AA. Complications Associated With the Use of the Recombinant Human Bone Morphogenetic Proteins for Posterior Interbody Fusions of the Lumbar Spine. Spine 2013, 38: e1020-e1027. PMID: 23629484, DOI: 10.1097/brs.0b013e3182982f8e.Peer-Reviewed Original Research
2007
Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. International Orthopaedics 2007, 31: 735-741. PMID: 17962946, PMCID: PMC2266670, DOI: 10.1007/s00264-007-0422-x.Peer-Reviewed Original ResearchMeSH KeywordsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationFractures, BoneFractures, UnunitedHumansOrthopedic ProceduresSpinal FusionTransforming Growth Factor betaConceptsBone morphogenetic protein-7Tibial fracturesSpinal fusionOP-1Bony fusion massDistal tibial fracturesLong bone nonunionOpen tibial fracturesRoute of administrationFuture clinical investigationsUse of BMPLong bone applicationsRecombinant human OP-1Collagen matrix resultsSupportive evidenceScaphoid nonunionClinical outcomesTibial nonunionClinical trialsClinical studiesBone nonunionClinical investigationNew therapeutic applicationsAnimal modelsMorphogenetic protein-7The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study
Vaccaro AR, Whang PG, Patel T, Phillips FM, Anderson DG, Albert TJ, Hilibrand AS, Brower RS, Kurd MF, Appannagari A, Patel M, Fischgrund JS. The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study. The Spine Journal 2007, 8: 457-465. PMID: 17588821, DOI: 10.1016/j.spinee.2007.03.012.Peer-Reviewed Original ResearchConceptsOP-1 PuttyUninstrumented fusionIliac crest autograftDegenerative spondylolisthesisOverall success rateAutograft patientsX-ray filmsAdverse eventsDecompressive laminectomyCrest autograftAutogenous boneShort Form Health Survey scoresForm Health Survey scoresBone graft substituteAutogenous iliac crest bone graftIliac crest bone graftPatient-reported outcome measuresPilot studyIntermediate-term efficacyOswestry Disability IndexPreoperative Oswestry scoreHealth Survey scoresPrimary efficacy endpointSF-36 scoresSymptomatic spinal stenosis