Secreted frizzled-related protein-4 reduces sodium–phosphate co-transporter abundance and activity in proximal tubule cells
Berndt T, Bielesz B, Craig T, Tebben P, Bacic D, Wagner C, O’Brien S, Schiavi S, Biber J, Murer H, Kumar R. Secreted frizzled-related protein-4 reduces sodium–phosphate co-transporter abundance and activity in proximal tubule cells. Pflügers Archiv - European Journal Of Physiology 2005, 451: 579-587. PMID: 16151791, DOI: 10.1007/s00424-005-1495-2.ChaptersMeSH KeywordsAnimalsCells, CulturedHumansKidney Tubules, ProximalMaleOpossumsProto-Oncogene ProteinsRatsRats, Sprague-DawleySodium-Phosphate Cotransporter Proteins, Type IIaConceptsSecreted frizzled-related protein 4Na+-dependent Pi uptakeRenal Pi excretionOpossum kidneyProximal tubulesPi excretionFractional excretion of PiResponse to hypophosphatemiaFrizzled-related protein 4Excretion of PiEffect of secreted frizzled-related protein 4Proximal tubule cellsBrush border of the proximal tubuleCo-transportNa+-dependent Pi transportRenal brush border membraneRenal BBMVOK cellsTubule cellsRenal phosphateSurface expressionTransporter abundanceBrush border membraneProtein 4Infusion