2024
Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81 PMID: 39476130, PMCID: PMC11581715, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchPrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsT4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS
Galimberti M, Gupta P, Deak J, Dao C, Nitin R, Zhou H, Harrington K, Na P, Topiwala A, Davis L, Gaziano M, Levey D, Stein M, Gelernter J. T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS. European Neuropsychopharmacology 2024, 87: 157-158. DOI: 10.1016/j.euroneuro.2024.08.314.Peer-Reviewed Original ResearchProtective effect of PAMental health traitsMillion Veteran ProgramEffects of PAGenome-wide association studiesPhysical activityLocal genetic correlationAlcohol consumptionPosttraumatic stress disorderSmoking initiationLeisure time PARelationship of PAUse disorderMental health outcomesPsychiatric disordersSelf-reported informationSubstance useAttention-deficit/hyperactivity disorderGenetic correlation analysisLocal genetic correlation analysisTime PAGenome-wide association study statisticsHealth traitsMR analysisResults PASuccessful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study
Shin J, Fischer I, Na P, Jeste D, Pietrzak R. Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2024 PMID: 39214753, DOI: 10.1016/j.jagp.2024.07.018.Peer-Reviewed Original ResearchGeneralized anxiety disorderPosttraumatic stress disorderMental disordersSomatic symptomsNational Health and ResilienceUS military veteransSuccessful agingAnxiety disordersDepressive disorderUS veteransStress disorderPromote successful agingHigher gratitudeVeterans StudyMilitary veteransInterventions targeting psychosocial factorsOne-in-fiveVeteransMDDDisordersPsychosocial factorsGratitudeNegative associationSymptomsMultivariate logistic regressionCo-occurring Chronic Pain and PTSD Among US Military Veterans: Prevalence, Correlates, and Functioning
Reed D, Fischer I, Williams R, Na P, Pietrzak R. Co-occurring Chronic Pain and PTSD Among US Military Veterans: Prevalence, Correlates, and Functioning. Journal Of General Internal Medicine 2024, 39: 2009-2016. PMID: 38780882, PMCID: PMC11306465, DOI: 10.1007/s11606-024-08803-w.Peer-Reviewed Original ResearchCo-occurring chronic painNationally representative sampleChronic painPosttraumatic stress disorderPsychosocial functioningUS veteransPatient Health Questionnaire-4Representative sampleShort-Form Health Survey-8Prevalence of chronic painNational Health and ResilienceAlcohol Use Disorders Identification TestChronic pain diagnosesDiagnosis of chronic painDisorders Identification TestCognitive Functioning ScaleMeasures of psychosocial functioningUS military veteransSelf-report itemsPosttraumatic Stress Disorder ChecklistHealth careVeterans StudyPain diagnosisFunctional scalesSuicidal Behaviors Questionnaire-RevisedFunctional significance of posttraumatic growth in U.S. military veterans
Gower T, Fischer I, Tsai J, Kang H, Na P, Tedeschi R, Pietrzak R. Functional significance of posttraumatic growth in U.S. military veterans. Journal Of Affective Disorders 2024, 356: 267-273. PMID: 38614442, DOI: 10.1016/j.jad.2024.04.046.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptomsPosttraumatic growthPsychosocial functioningTraumatic eventsTrauma-exposed U.S. veteransNational Health and ResilienceMale veteran samplePost-trauma functioningPattern of findingsRetrospective self-reportsU.S. military veteransVeteran sampleStress disorderVeterans StudyExamined relationsCross-sectional designMilitary veteransNationally representative sampleU.S. veteransAssociated with functionsPhysical functionClinical interventionsPsychosocial characteristicsVeteransProblem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics
Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024, 18: 313-318. PMID: 38498625, PMCID: PMC11150085, DOI: 10.1097/adm.0000000000001286.Peer-Reviewed Original ResearchInstrumental activities of daily livingInstrumental activities of daily living disabilityLifetime suicide attemptsProblem opioid useUS military veteransUS veteransPsychiatric characteristicsSuicide attemptsMilitary veteransAssociated with black race/ethnicityActivities of daily livingNational Health and ResilienceLifetime alcohol use disorderMental health morbidityPosttraumatic stress disorderMental health disordersAlcohol use disorderNon-Hispanic race/ethnicityMultivariate logistic regression modelNationally representative sampleOpioid useLogistic regression modelsInstrumental activitiesHealth morbidityDaily livingGenetic and non-genetic predictors of risk for opioid dependence.
Na P, Deak J, Kranzler H, Pietrzak R, Gelernter J. Genetic and non-genetic predictors of risk for opioid dependence. Psychological Medicine 2024, 54: 1779-1786. PMID: 38317430, PMCID: PMC11132928, DOI: 10.1017/s0033291723003732.Peer-Reviewed Original ResearchPolygenic risk scoresMulti-trait analysis of genome-wide association studyOpioid use disorderPosttraumatic stress disorderPsychosocial/environmental factorsAnalysis of genome-wide association studiesHigher education levelGenome-wide association studiesNon-genetic predictorsEuropean-ancestry adultsEtiology of ODPublic health crisisPsychosocial factorsPolygenic riskMulti-trait analysisEducation levelPsychosocial environmentHousehold incomeRisk scoreAssociation studiesOpioid dependenceDiagnosis of ODLifetime diagnosisYale-PennAssociated with OD
2023
Changes in mental health among U.S. military veterans during the COVID-19 pandemic: A network analysis
Spiller T, Na P, Merians A, Duek O, Ben-Zion Z, Tsai J, von Känel R, Harpaz-Rotem I, Pietrzak R. Changes in mental health among U.S. military veterans during the COVID-19 pandemic: A network analysis. Journal Of Psychiatric Research 2023, 165: 352-359. PMID: 37595331, DOI: 10.1016/j.jpsychires.2023.08.003.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSymptoms of PTSDTraumatic eventsPosttraumatic growthU.S. military veteransPTSD symptomsSuicidal ideationMental healthMilitary veteransIncrease of symptomsPopulation-based sampleCOVID-19 pandemicFirst yearStress disorderMost veteransSymptomsFirst monthPsychopathological symptomsGeneral resilienceGroup levelAnxietyVeteransIndividual reactionsDepressionSubtle increasePurpose in life protects against the development of suicidal thoughts and behaviors in U.S. veterans without a history of suicidality: A 10-year, nationally representative, longitudinal study
Fischer I, Nichter B, Feldman D, Na P, Tsai J, Harpaz-Rotem I, Schulenberg S, Pietrzak R. Purpose in life protects against the development of suicidal thoughts and behaviors in U.S. veterans without a history of suicidality: A 10-year, nationally representative, longitudinal study. Journal Of Affective Disorders 2023, 340: 551-554. PMID: 37557988, DOI: 10.1016/j.jad.2023.08.040.Peer-Reviewed Original ResearchConceptsIncident suicidal ideationAlcohol use disorderIncident suicide attemptsCurrent alcohol use disorderHistory of STBSuicidal ideationSuicide attemptsBaseline predictorsDaily livingPopulation-based prospective cohort studySuicidal thoughtsLow purposeCurrent posttraumatic stress disorderProspective cohort studyTraditional risk factorsLower annual household incomeMultivariable regression analysisEvidence-based interventionsUS military veteransPosttraumatic stress disorderAnnual household incomeCohort studyTrauma burdenRisk factorsNational HealthCOVID-19-related media consumption and posttraumatic stress symptoms in U.S. military veterans: A nationally representative, longitudinal study
Whealin J, Fischer I, Na P, Pietrzak R. COVID-19-related media consumption and posttraumatic stress symptoms in U.S. military veterans: A nationally representative, longitudinal study. Psychiatry Research 2023, 326: 115354. PMID: 37480676, DOI: 10.1016/j.psychres.2023.115354.Peer-Reviewed Original ResearchFunctional Disability in US Military Veterans: The Importance of Integrated Whole Health Initiatives.
Meisler A, Gianoli M, Na P, Pietrzak R. Functional Disability in US Military Veterans: The Importance of Integrated Whole Health Initiatives. The Primary Care Companion For CNS Disorders 2023, 25 PMID: 37419488, DOI: 10.4088/pcc.22m03461.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderIADL disabilityFunctional disabilityInstrumental ADLUS veteransCognitive disordersOlder ageDeployment-related injuryUS veteran populationUS military veteransLow incomeADL disabilityChronic painMale sexBlack raceClinical managementRisk factorsNational HealthSleep disordersDaily livingPsychiatric correlatesFunctional capacityVeteran populationDisability riskHealth initiativesTrajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study
Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.Peer-Reviewed Original ResearchConceptsAlcohol consumption groupCurrent mental health treatmentDysphoric arousal symptomsMental health treatmentUS veteransAlcohol consumptionHealth treatmentConsumption groupArousal symptomsYounger agePopulation-based longitudinal studyPublic health problemLongitudinal studyExcessive alcohol consumptionAlcohol use disorderPosttraumatic stress disorderU.S. military veteransMedical comorbiditiesChronic courseNational HealthClose monitoringUse disordersHealth problemsVeterans StudyStress disorder
2022
Mental health of U.S. combat veterans by war era: Results from the National health and Resilience in veterans study
Na P, Schnurr P, Pietrzak R. Mental health of U.S. combat veterans by war era: Results from the National health and Resilience in veterans study. Journal Of Psychiatric Research 2022, 158: 36-40. PMID: 36565542, DOI: 10.1016/j.jpsychires.2022.12.019.Peer-Reviewed Original ResearchConceptsIraq/Afghanistan war veteransAfghanistan war veteransPosttraumatic stress disorderUS combat veteransNational HealthUse disordersWar veteransCurrent drug use disordersCombat veteransCurrent major depressive disorderCombat exposure severityCurrent alcohol use disorderEra veteransLifetime posttraumatic stress disorderAdverse psychiatric outcomesDrug use disordersMajor depressive disorderGulf War veteransCurrent suicidal thoughtsMental health factorsAlcohol use disorderCurrent suicidal ideationTrauma burdenDepressive disorderERA groupMoral injury among U.S. combat veterans with and without PTSD and depression
Norman SB, Nichter B, Maguen S, Na PJ, Schnurr PP, Pietrzak RH. Moral injury among U.S. combat veterans with and without PTSD and depression. Journal Of Psychiatric Research 2022, 154: 190-197. PMID: 35947898, DOI: 10.1016/j.jpsychires.2022.07.033.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderPosttraumatic stress disorderCombat veteransInjurious eventsU.S. combat veteransProbable depressionFunctional impairmentMost veteransStress disorderDepressionVeteransPrevalenceDisordersRepresentative studyRepresentative sampleMoral injuryPMIEsParticipantsMental Health Burden in Enlisted and Commissioned U.S. Military Veterans: Importance of Indirect Trauma Exposure in Commissioned Veterans
Merians AN, Na PJ, Tsai J, Harpaz-Rotem I, Pietrzak RH. Mental Health Burden in Enlisted and Commissioned U.S. Military Veterans: Importance of Indirect Trauma Exposure in Commissioned Veterans. Psychiatry 2022, 85: 418-432. PMID: 35532217, DOI: 10.1080/00332747.2022.2068301.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMajor depressive disorderU.S. military veteransSuicidal ideationMilitary veteransTrauma exposureMost mental health outcomesMental health burdenPast-year suicidal ideationDrug use disordersU.S. veteran populationMental health historyHigh exposureMental health outcomesMultivariable analysisDepressive disorderNational HealthHealth burdenPost-stratification weightsUse disordersVeteran populationHealth historyHealth outcomesIndirect trauma exposureVeterans StudyMilitary sexual trauma in the United States: Results from a population-based study
Nichter B, Holliday R, Monteith LL, Na PJ, Hill ML, Kline AC, Norman SB, Pietrzak RH. Military sexual trauma in the United States: Results from a population-based study. Journal Of Affective Disorders 2022, 306: 19-27. PMID: 35301038, DOI: 10.1016/j.jad.2022.03.016.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaCurrent posttraumatic stress disorderPopulation-based studyPosttraumatic stress disorderMST historyMale veteransGreater oddsFemale veteransHealth burdenPsychosocial functioningSexual traumaGeneral veteran populationPopulation-based surveyPrevalence of MSTMental health treatmentSex-stratified associationsCross-sectional designPsychiatric comorbidityNational HealthTreatment utilizationVeteran populationHealth treatmentSuicidal intentVeterans StudySomatic symptomsCannabis use among U.S. military veterans with subthreshold or threshold posttraumatic stress disorder: Psychiatric comorbidities, functioning, and strategies for coping with posttraumatic stress symptoms
Hill ML, Loflin M, Nichter B, Na PJ, Herzog S, Norman SB, Pietrzak RH. Cannabis use among U.S. military veterans with subthreshold or threshold posttraumatic stress disorder: Psychiatric comorbidities, functioning, and strategies for coping with posttraumatic stress symptoms. Journal Of Traumatic Stress 2022, 35: 1154-1166. PMID: 35275431, DOI: 10.1002/jts.22823.Peer-Reviewed Original ResearchConceptsU.S. military veteransFull PTSDCannabis usePTSD symptomsPosttraumatic stress disorder (PTSD) symptomsThreshold Posttraumatic Stress DisorderMilitary veteransPosttraumatic stress symptomsPosttraumatic stress disorderPsychiatric symptomsFrequent cannabis useMental health treatmentCurrent psychiatric symptomsCo-occurring depressionCognitive functioningBehavioral disengagementDisorder symptomsStress disorderStress symptomsFrequent cannabisTreatment engagementPTSDVeterans StudyHealth treatmentSubstance use
2021
Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic
Nichter B, Hill ML, Na PJ, Kline AC, Norman SB, Krystal JH, Southwick SM, Pietrzak RH. Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2021, 78: 1218-1227. PMID: 34431973, PMCID: PMC8387942, DOI: 10.1001/jamapsychiatry.2021.2332.Peer-Reviewed Original ResearchConceptsUS military veteransCOVID-19 infectionCohort studySuicidal behaviorPast-year suicide ideationRisk factorsMilitary veteransPopulation-based prospective cohort studyCOVID-19 pandemicSuicide ideationSuicide attemptsProspective cohort studyLifetime posttraumatic stress disorderStrong risk factorCOVID-19 public health emergencyLow social supportPosttraumatic stress disorderPublic health emergencyAlcohol use disorder severityUS veteransNational HealthMAIN OUTCOMESuicide attempt historyVeterans StudyCOVID-19-related variablesFactors associated with post-traumatic growth in response to the COVID-19 pandemic: Results from a national sample of U.S. military veterans
Na PJ, Tsai J, Southwick SM, Pietrzak RH. Factors associated with post-traumatic growth in response to the COVID-19 pandemic: Results from a national sample of U.S. military veterans. Social Science & Medicine 2021, 289: 114409. PMID: 34537394, PMCID: PMC8445520, DOI: 10.1016/j.socscimed.2021.114409.Peer-Reviewed Original ResearchConceptsPost-traumatic growthPosttraumatic stress disorderPTSD symptomsU.S. military veteransPositive psychological changesNegative psychological outcomesMilitary veteransU.S. veteransNational samplePrior traumatic eventsAvoidance symptomsTrauma survivorsPsychological outcomesTraumatic eventsPsychological changesPsychosocial interventionsStress disorderPsychological distressPsychological impactCOVID-19 pandemicMajority of researchVeterans StudyMental healthLongitudinal studyFunctional correlates