1986
Expression of differentiation antigens by hybrids of human lymphoblastoid cells
Howell D, Salter R, Koppelman B, Cresswell P. Expression of differentiation antigens by hybrids of human lymphoblastoid cells. Human Immunology 1986, 17: 443-455. PMID: 3098709, DOI: 10.1016/0198-8859(86)90303-4.Peer-Reviewed Original ResearchConceptsParent cell lineCell linesClass IClass II antigensB lymphocyte antigensClass II histocompatibility antigensLymphocyte differentiation markersT-lymphoblastoid cell lineII antigensHistocompatibility antigensLymphocyte antigenDifferentiation antigensLymphoblastoid cell linesParental antigensHNK-1AntigenMonoclonal antibodiesHuman lymphoblastoid cellsT-LCLDifferentiation markersLymphoblastoid cellsCurrent study
1985
Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression
Carrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression. Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.Peer-Reviewed Original ResearchConceptsGene expressionDNA methylationLymphoblastoid cell linesRegulatory mechanismsDNA hypomethylationParental linesHybrid linesSomatic cell hybridsRestriction enzyme Hpa IIHpa II digestionMsp I siteDifferent regulatory mechanismsCell hybridsGenomic probesGene inductionUnexpressed genesComplete demethylationHpa IIGenesDR genesMethylationT-LCLCell linesI siteHypomethylationGenes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter R, Howell D, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 1985, 21: 235-246. PMID: 3872841, DOI: 10.1007/bf00375376.Peer-Reviewed Original ResearchConceptsHLA class IClass II antigen expressionClass II antigensHLA-B antigensClass III antigensAntigen expressionLymphoblastoid cell linesTotal HLA class IHLA class II antigensHLA-A2 antigenHLA-B5 antigenHLA-A antigensB-lymphoblastoid cell linesCell linesHLA-DRHLA-B5HLA-A2B-LCLParental cell lineAntigenEnhanced expressionDecreased amountCEMRChromosome 6
1984
Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids
Howell D, Kostyu D, Ting J, Cresswell P. Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. Somatic Cell And Molecular Genetics 1984, 10: 217-224. PMID: 6609440, DOI: 10.1007/bf01535244.Peer-Reviewed Original ResearchConceptsClass I histocompatibilityB-LCLLymphoblastoid cell linesB antigensPaucity of HLAHLA class I heavy chainsHLA-B antigensHLA-A antigensB-lymphoblastoid cell linesB antigen expressionClass I heavy chainsAntigen expressionB expressionHLAIndirect immunofluorescenceAntigenLow levelsClass IT-LCLHistocompatibilityCell linesHeavy chain mRNATotal levelsCEMRHeavy chain
1983
Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids
Howell D, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids. Immunogenetics 1983, 17: 411-425. PMID: 6601057, DOI: 10.1007/bf00372459.Peer-Reviewed Original Research
1979
Transferrin receptors on human B and T lymphosblastoid cell lines
Larrick J, Cresswell P. Transferrin receptors on human B and T lymphosblastoid cell lines. Biochimica Et Biophysica Acta 1979, 583: 483-490. PMID: 218639, DOI: 10.1016/0304-4165(79)90065-5.Peer-Reviewed Original Research
1977
Human B cell alloantigens: separation from other membrane molecules by affinity chromatography
Cresswell P. Human B cell alloantigens: separation from other membrane molecules by affinity chromatography. European Journal Of Immunology 1977, 7: 636-639. PMID: 303569, DOI: 10.1002/eji.1830070911.Peer-Reviewed Original ResearchConceptsMolecular weight 35 000Sodium dodecyl sulfate gel electrophoresisDodecyl sulfate gel electrophoresisAffinity chromatographySulfate gel electrophoresisSoluble productsB-lymphoblastoid cell linesChromatographyMoleculesSodium deoxycholateLymphoblastoid cell linesGel electrophoresisAgarose columnIa-like alloantigensDeoxycholateCell linesHuman B cellsSeparationSpecific rabbit antibodiesB cellsColumnSerological activityElectrophoresisRabbit antibodiesMaterialsRobbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte response
Geier S, Cresswell P. Robbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte response. Cellular Immunology 1977, 28: 341-354. PMID: 139207, DOI: 10.1016/0008-8749(77)90117-4.Peer-Reviewed Original ResearchConceptsMixed lymphocyte responseB-lymphoblastoid cell linesHuman B lymphoblastoid cell lineB-cell alloantigensLymphoblastoid cell linesT-lymphoblastoid cell lineLymphocyte responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsPeripheral blood B lymphocytesHuman B cell alloantigensBlood B lymphocytesBlood mononuclear cellsHuman B cellsMononuclear cellsT lymphocytesB cellsB lymphocytesContinuous stimulationLymphocytesFab preparationsAlloantigensCell lines
1976
HLA‐B specificities and w4, w6 specificities are on the same polypeptide
Ayres J, Cresswell P. HLA‐B specificities and w4, w6 specificities are on the same polypeptide. European Journal Of Immunology 1976, 6: 794-799. PMID: 63373, DOI: 10.1002/eji.1830061108.Peer-Reviewed Original ResearchConceptsHLA-B7HLA-B12HLA-B determinantsAntigenic determinantsDistinct antigenic determinantsDifferent antigenic determinantsHLA-B specificitiesHLA-B locusHLA-B locus productsSequential immunoprecipitation experimentsLymphoblastoid cell linesAntigen poolCell linesLocus productsHunter reagentSpecificityImmunoprecipitation experimentsPapain digestionDeterminantsDiallelic systemAlloantiseraSame polypeptide