FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Chen M, Cavinato C, Hansen J, Tanaka K, Ren P, Hassab A, Li D, Youshao E, Tellides G, Iyengar R, Humphrey J, Schwartz M. FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: e132-e150. PMID: 36994727, PMCID: PMC10133209, DOI: 10.1161/atvbaha.123.319120.Peer-Reviewed Original ResearchConceptsContractile gene expressionSmooth muscle cellsGene expressionMgR miceWild-type smooth muscle cellsMarfan miceAortic aneurysmMouse modelMarfan syndromeMouse aortic smooth muscle cellsPathogenesis of TAACytoplasmic domainVascular smooth muscle cellsThoracic aortic aneurysmAortic smooth muscle cellsCultured smooth muscle cellsNF-kB activationNF-kB inhibitionMolecular mechanismsIntegrin α2ECM remodelingElastic fiber integrityPhenotypic modulationMarfan's aneurysmsMgR/Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells.
Jiang B, Li X, Wang M, Li G, Ren P, Wang Y, Xin S, Qin L. Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells. Journal Of Geriatric Cardiology 2023, 20: 214-222. PMID: 37091261, PMCID: PMC10114191, DOI: 10.26599/1671-5411.2023.03.002.Peer-Reviewed Original ResearchElastase-induced abdominal aortic aneurysmContractile phenotypeAbdominal aortic aneurysm (AAAGieson stainingVehicle-treated miceMeasuring aortic diameterAbdominal aortic aneurysm formationAortic aneurysm formationAbdominal aortic aneurysmTrehalose-treated groupSmooth muscle cellsExpression of autophagy markersVerhoeff-Van Gieson stainSmooth muscle cell contractile phenotypeAutophagy inducerAorta dilatationAortic diameterLeukocyte infiltrationAortic aneurysmVascular histologyDecreased inflammationAAA progressionMouse modelAbdominal aortaMuscle cells