Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies
Lembo A, Staller K, Boules M, Feuerstadt P, Spalding W, Gabriel A, Youssef A, Xie Y, Terreri B, Cash B. Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies. Therapeutic Advances In Gastroenterology 2024, 17: 17562848241299731. PMID: 39664231, PMCID: PMC11632959, DOI: 10.1177/17562848241299731.Peer-Reviewed Original ResearchChronic idiopathic constipationBody mass indexSafety of prucalopridePlacebo-treated patientsRenal functionRenal impairmentEfficacy endpointIdiopathic constipationMass indexClinical studiesTreatment-related adverse eventsPlacebo-controlled clinical studyRenal impairment subgroupsMild renal impairmentModerate renal impairmentNormal renal functionProportion of patientsPost hoc analysisUnderweight/healthy weightAdverse eventsPrucaloprideIII and IVSafety dataPatientsTreating adults