2024
Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study.
Nellis M, Chegondi M, Willems A, Alqatani M, McMichael A, Aran A, Lerner R, Karam O. Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study. Pediatric Critical Care Medicine 2024 PMID: 39560732, DOI: 10.1097/pcc.0000000000003638.Peer-Reviewed Original ResearchCritically ill childrenAssessment ScaleIll ChildrenBleeding severityIntra-rater reliabilityInter-rater reliabilityCohort of critically ill childrenChildren aged 0Prospective cohort studyAssociated with increased 28-day mortalityEvaluation of bleedingActivated partial thromboplastin timeBedside nursesPatient demographic dataPartial thromboplastin timeTransfused blood componentsLonger hospital lengthParticipating PICUsCohort studyHemostatic medicationsDiverse cohortInotropic supportBleeding eventsSevere bleedingPlatelet countComprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study.
Hughes T, Treffalls R, Koek W, Dalton H, Karam O, Meyer A. Comprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study. Perfusion 2024, 2676591241289358. PMID: 39352407, DOI: 10.1177/02676591241289358.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationMultiple thrombotic eventsThrombotic eventsMembrane oxygenationPediatric extracorporeal membrane oxygenationMulti-center prospective studyEvaluate predictive factorsDays of therapyPlatelet transfusion volumeProspective cohort studyTransfusion volumeBinomial regressionPediatric patientsProlonged ECMOPlatelet volumePredictive factorsProspective studyUnivariate analysisAnti-XaCohort studySeverity scoreHigh riskPatientsAntithrombin IIIScoring tool
2023
Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study
Levasseur J, Fikse L, Mauguen A, Killinger J, Karam O, Nellis M. Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study. Pediatric Critical Care Medicine 2023, 24: e602-e610. PMID: 37678406, PMCID: PMC10843653, DOI: 10.1097/pcc.0000000000003374.Peer-Reviewed Original ResearchConceptsProspective cohort studyBleeding episodesSevere bleedingIll childrenCohort studyCell transplantIncidence rateLaboratory valuesMinimal bleedingRadiation therapySingle-center prospective cohort studyAssociated Patient CharacteristicsHigher PICU mortalityNew bleeding episodesOnly laboratory valueHematopoietic cell transplantCritically Ill ChildrenLow platelet countSevere bleeding episodesStem cell transplantPatient demographic dataSpecialized cancer hospitalModerate bleeding episodesYears of ageLonger PICU
2019
Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity.
Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O. Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity. Critical Care Medicine 2019, 47: 1766-1772. PMID: 31567407, PMCID: PMC6861687, DOI: 10.1097/ccm.0000000000004025.Peer-Reviewed Original ResearchConceptsIll childrenAssessment ScaleDiagnostic criteriaProspective cohort studyRed cell transfusionCritically Ill ChildrenFuture epidemiologic studiesDelphi consensus processInternational expert consensusRounds of votingBleeding severityRelevant bleedingSubstantial inter-rater reliabilityBleeding episodesCell transfusionCohort studyCritical illnessOrgan dysfunctionOnline Delphi processSurgical interventionPediatric intensivistsPatient outcomesInter-rater reliabilityEpidemiologic studiesExpert consensus
2018
Platelet Transfusion Practices in Critically Ill Children
Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsCells/LMajor bleedingProphylactic transfusionICU mortalityMinor bleedingIll childrenOverall ICU mortalityPediatric critical illnessPlatelet transfusion practicesProspective cohort studyProphylactic platelet transfusionsCohort studyCritical illnessPost transfusionAdjusted analysisPlatelet countTransfusion practiceAppropriate indicationsMedian changePlatelet doseTransfusionBleedingCells/L.Prophylaxis