2016
The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis
Karam O, Gebistorf F, Wetterslev J, Afshari A. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis. Anaesthesia 2016, 72: 106-117. PMID: 27762438, DOI: 10.1111/anae.13628.Peer-Reviewed Original ResearchInhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
Gebistorf F, Karam O, Wetterslev J, Afshari A. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. 2016, 2018: cd002787. PMID: 27347773, PMCID: PMC6464789, DOI: 10.1002/14651858.cd002787.pub3.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAcute hypoxaemic respiratory failureTrial sequential analysisEffects of iNORespiratory distress syndromeINO groupControl groupDistress syndromeNitric oxideRisk ratioSecondary objectiveHypoxaemic respiratory failureTrial methodological componentsVentilator-free daysCochrane Central RegisterPrimary outcome measureEffect of administrationLength of stayRisk of biasConfidence intervalsAllied Health LiteratureSearch of MEDLINELevel of evidenceEffects of interventionsNitric oxide results
2013
Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.Peer-Reviewed Original ResearchConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeIntensive care unit lengthPlasma transfusionDysfunction syndromeClinical outcomesIll childrenNosocomial infectionsCare unitOdds ratioOutcome measuresPediatric intensive care unitPediatric critical care unitProspective pediatric studiesAdult trauma patientsProspective observational studySingle-center studySecondary outcome measuresWorse clinical outcomesExtracorporeal life supportPrimary outcome measureSeverity of illnessIntensive care unitCritical care units
2010
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitMultiple organ dysfunction syndromeRed blood cell unitsOrgan dysfunction syndromeDysfunction syndromeIll childrenPICU lengthClinical outcomesOdds ratioObservational studyMultiple logistic regression modelProspective observational studyWorse clinical outcomesPrimary outcome measureIntensive care unitNorth American centersCell unitsLogistic regression modelsSecondary outcomesConsecutive patientsOrgan dysfunctionCare unitMedian lengthProspective studyClinical impact