2021
Epidemiology of Bleeding in Critically Ill Children
Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.Peer-Reviewed Original ResearchPediatric critical care unitRisk of mortalityCritical care unitsIll childrenCare unitClinical outcomesProspective observational cohort studyEpidemiology of BleedingPICU-free daysPercent of patientsVentilator-free daysDuration of surgeryObservational cohort studyCritically Ill ChildrenWorse clinical outcomesType of surgeryFurther multicenter studiesHigher severityCohort studyCritical illnessPediatric IndexSevere complicationsConsecutive patientsIll patientsMedian ageCompliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*
Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPositive respiratory culturesRespiratory culturesAntibiotic continuationPhase 3 subjectsRespiratory culture resultsVentilator-Associated InfectionsObservational cohort studyOverall study populationBaseline data collectionPhase 1Antibiotic discontinuationAntibiotic recommendationsAntibiotic guidelinesAntibiotic decisionsCohort studyGuideline adherenceMicrobiologic dataIllness severityMechanical ventilationAntibiotic managementRespiratory secretionsAntibiotic utilizationConsensus guidelinesAntibiotic treatment
2020
Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound
Greenfield KD, Karam O, O'Meara A. Brighter Days May Be Ahead: Continuous Measurement of Pediatric Intensive Care Unit Light and Sound. Frontiers In Pediatrics 2020, 8: 590715. PMID: 33194924, PMCID: PMC7649178, DOI: 10.3389/fped.2020.590715.Peer-Reviewed Original ResearchPediatric intensive care unitCourse of admissionIll childrenTertiary care pediatric intensive care unitProspective observational cohort studyPost-intensive care syndromeObservational cohort studyIntensive care unitModifiable environmental factorsMedian illuminancePatients 0Cardiovascular supportCohort studyCare unitClinical effectsPatientsMedian light levelsSleep/AdmissionSound levelsMedian sound levelChildrenUnit lightHoursLevelsAssociation Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass
Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.Peer-Reviewed Original ResearchPediatric critical care unitPICU admissionSystemic oxygen deliveryCardiopulmonary bypassCritical care unitsOxygen extractionBlood glucoseOxygen deliveryCardiac surgeryCare unitLow systemic oxygen deliveryObservational cohort studyDuration of bypassWorse clinical outcomesHigher oxygen extractionLogistic regression modelsCohort studyCardiac lesionsClinical outcomesSurrogate markerPyruvate ratioAdmissionHyperlactatemiaSame timepointsBypassEpidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation.
Karam O, Goel R, Dalton H, Nellis ME. Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. Critical Care Medicine 2020, 48: e698-e705. PMID: 32697511, DOI: 10.1097/ccm.0000000000004417.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkChest tube outputMembrane oxygenationHemostatic transfusionsRBC transfusionTransfusion doseExtracorporeal membrane oxygenation daysLarge observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkTube outputPlatelet transfusion doseObservational cohort studyHuman Development Collaborative Pediatric Critical Care Research NetworkInternational normalized ratioTotal platelet countPartial thromboplastin timeAntithrombin levelsCohort studyConsecutive childrenTransfusion strategyChest tubePlatelet countHemostatic testing
2019
Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome.
Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.Peer-Reviewed Original ResearchConceptsChest tube bleedingExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkMembrane oxygenationChest tubeClinical outcomesPlatelet countML/Large observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkPICU-free daysPercent of patientsObservational cohort studyWorse clinical outcomesHuman Development Collaborative Pediatric Critical Care Research NetworkMembrane oxygenation specialistsHospital mortalityTransfusion volumeCohort studyHeparin doseConsecutive patientsThrombotic eventsPediatric institutionHemostatic tests