2011
Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice
Parker JG, Wanat MJ, Soden ME, Ahmad K, Zweifel LS, Bamford NS, Palmiter RD. Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice. Journal Of Neuroscience 2011, 31: 17103-17112. PMID: 22114279, PMCID: PMC3235504, DOI: 10.1523/jneurosci.1715-11.2011.Peer-Reviewed Original ResearchConceptsDA neuronsDA neuron activityGABAA Receptor SignalingPhasic dopamine transmissionPhasic DA responsesAversive learningAppetitive learningGABAergic toneExcitatory afferentsMidbrain slicesDA releaseDopamine neuronsExcitatory driveDopamine transmissionNucleus accumbensDA responseElectrical stimulationNeuron activityDA signalingPsychiatric conditionsCompensatory upregulationMiceNeuronsReceptor signalingAppetitive task
2010
Chapter 35 Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases
Cepeda C, Bamford N, André V, Levine M. Chapter 35 Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases. Techniques In The Behavioral And Neural Sciences 2010, 20: 607-623. DOI: 10.1016/b978-0-12-374767-9.00035-4.Peer-Reviewed Original ResearchMedium-sized spiny neuronsParkinson's diseaseHuntington's diseaseCorticostriatal pathwayCortico-basal ganglia-thalamocortical loopsCorticostriatal synaptic functionBasal ganglia neuronsVariety of interneuronsGenetic mouse modelsPrincipal cell typesCoordinated preDA neuronsPostsynaptic actionsMotor disturbancesGanglion neuronsSpiny neuronsCortical neuronsElectrophysiological changesMouse modelSynaptic inputsAnimal modelsEventual degenerationSynaptic functionSubsequent degenerationPD model