2006
Hypoglycemia reduces the blood‐oxygenation level dependent signal in primary auditory and visual cortex: A functional magnetic resonance imaging study
Driesen NR, Goldberg PA, Anderson AW, Tang L, Flanagan DE, Sherwin RS, Gore JC. Hypoglycemia reduces the blood‐oxygenation level dependent signal in primary auditory and visual cortex: A functional magnetic resonance imaging study. Journal Of Neuroscience Research 2006, 85: 575-582. PMID: 17154420, DOI: 10.1002/jnr.21146.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingFunctional magnetic resonance imagingModerate hypoglycemiaVisual cortexResonance imagingCentral nervous system effectsMagnetic resonance imaging studyNon-diabetic controlsNon-diabetic participantsNervous system effectsBlood oxygenation level-dependent (BOLD) signalFrequent hypoglycemic episodesBlood oxygenation level-dependent (BOLD) responseEffects of hypoglycemiaResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent signalLevel-dependent responsesVisual stimuliHypoglycemic episodesT1DM patientsPrimary auditoryEuglycemic periodHypoglycemic responseNeurophysiologic changes
1995
Reaction Time Impairment in Insulin-Dependent Diabetes: Task Complexity, Blood Glucose Levels, and Individual Differences
Driesen N, Cox D, Gonder-Frederick L, William C. Reaction Time Impairment in Insulin-Dependent Diabetes: Task Complexity, Blood Glucose Levels, and Individual Differences. Neuropsychology 1995, 9: 246-254. DOI: 10.1037/0894-4105.9.2.246.Peer-Reviewed Original ResearchIndividual differencesRT taskReaction timeComplex RT tasksCognitive processing speedIndividual difference variablesMeasures cross-over designReaction time impairmentsSimple RT taskTest 4 timesCognitive slowingDifference variablesTask complexityProcessing speedHypoglycemia sensitivityParticipantsCross-over designTaskEffects of hypoglycemiaModerate hypoglycemiaImpairmentExperimental daysAdultsIndividualsDay protocol
1994
Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM
Gonder-Frederick L, Cox D, Driesen N, Ryan C, Clarke W. Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM. Diabetes 1994, 43: 1407-1412. PMID: 7958491, DOI: 10.2337/diab.43.12.1407.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusModerate hypoglycemiaDegree of impairmentHistory of unconsciousnessNeurobehavioral deteriorationDiabetes mellitusGlycemic thresholdsTest four timesMild hypoglycemiaDay protocolNeurobehavioral disruptionNeurobehavioral effectsGlycemic recoveryHypoglycemiaMore deteriorationRepeat testingCrossover designControl dayDeterioration scoresConsecutive daysExperimental daysImpairment