2001
Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity
Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension 2001, 37: 46-51. PMID: 11208755, DOI: 10.1161/01.hyp.37.1.46.Peer-Reviewed Original ResearchACE insertion/deletion polymorphismGreater vasodilator responseVasodilator responseACE D alleleSodium nitroprussideInsertion/deletion polymorphismVascular reactivityEndothelium-independent vasodilator sodium nitroprussideD allelePotent endothelium-dependent vasodilatorVascular smooth muscle reactivityACE I/D genotypeEffect of angiotensinForearm blood flowSmooth muscle reactivityEndothelium-dependent vasodilatorVasodilator sodium nitroprussideDeletion polymorphismTreatment of hypertensionACE gene locusVascular sensitivityNormotensive subjectsNormotensive blacksVenous plethysmographyBlood pressure
1999
α1A-Adrenergic receptor polymorphism
Xie H, Kim R, Stein C, Gainer J, Brown N, Wood A. α1A-Adrenergic receptor polymorphism. Pharmacogenetics And Genomics 1999, 9: 651-656. DOI: 10.1097/01213011-199910000-00012.Peer-Reviewed Original ResearchΑ1A-ARAfrican AmericansPrevalence of hypertensionPathogenesis of hypertensionVascular smooth muscleΑ1-adrenergic receptorsΑ1-adrenergic responsesCaucasian individualsEthnic differencesΑ1-AR subtypesVasoconstrictor sensitivityVascular reactivityBlood pressureEssential hypertensionHypertensive individualsVascular responsesVascular toneΑ1-ARReceptor polymorphismsSmooth muscleHypertensionSignificant intergenotypic differencesPotential roleRestriction fragment length polymorphismAllelic distributionα1A-Adrenergic receptor polymorphism
Xie H, Kim R, Stein C, Gainer J, Brown N, Wood A. α1A-Adrenergic receptor polymorphism. Pharmacogenetics And Genomics 1999, 9: 651-656. PMID: 10591546, DOI: 10.1097/00008571-199910000-00012.Peer-Reviewed Original ResearchConceptsAlpha1A-ARAfrican AmericansPrevalence of hypertensionPathogenesis of hypertensionAlpha1-adrenergic receptorsAlpha1-AR subtypesVascular smooth muscleCaucasian individualsEthnic differencesVasoconstrictor sensitivityVascular reactivityAlpha1-ARBlood pressureEssential hypertensionHypertensive individualsVascular responsesVascular toneReceptor polymorphismsSmooth muscleHypertensionSignificant intergenotypic differencesPotential roleRestriction fragment length polymorphismAllelic distributionFragment length polymorphism