2018
The Vasculature in Prediabetes
Wasserman DH, Wang TJ, Brown NJ. The Vasculature in Prediabetes. Circulation Research 2018, 122: 1135-1150. PMID: 29650631, PMCID: PMC5901903, DOI: 10.1161/circresaha.118.311912.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme InhibitorsAnimalsBlood VesselsCardiovascular DiseasesCombined Modality TherapyDiabetes Mellitus, Type 2Diet, ReducingDisease ProgressionEndothelium, VascularExtracellular MatrixFatty Acids, NonesterifiedFibrinolysisGlucoseHumansHyperglycemiaHypoglycemic AgentsInflammationInsulin ResistanceLife StyleMetabolic SyndromeMiceMicrocirculationMicroRNAsMuscle, SkeletalObesityPrediabetic StateRiskWeight LossConceptsFrequency of prediabetesMainstay of treatmentPrevalence of obesityConcomitant obesityEndothelial dysfunctionExtracellular matrix remodelingDiabetes mellitusEndothelial functionRenal diseaseMetabolic derangementsFibrinolytic dysfunctionEndothelial vasodilatorsInsulin resistanceInsulin sensitivityCardiovascular diseaseDelivery of insulinSlow progressionPrediabetesWeight lossSkeletal muscleMatrix remodelingMellitusObesityDysfunctionDisease
2016
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease
Gamboa JL, Billings FT, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ, Himmelfarb J, Ikizler TA, Brown NJ. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiological Reports 2016, 4: e12780. PMID: 27162261, PMCID: PMC4873632, DOI: 10.14814/phy2.12780.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCKD stage 5Peripheral blood mononuclear cellsSeverity of CKDCKD stage 3Kidney diseaseOxidative stressF2-isoprostanesMtDNA copy numberMuscle biopsyMitochondrial volume densitySkeletal muscleDifferent CKD stagesMitochondrial dysfunctionBlood mononuclear cellsStage 3Stage 5Skeletal muscle biopsiesLower mtDNA copy numberMitochondrial DNA copy numberPlasma isofuransCKD stageMuscle dysfunctionMononuclear cellsFunction worsens