2016
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Thomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusBloodstream infectionsPhagocytic killingElicit cross-protective immune responsesCross-protective immune responsesProtective fibrin shieldS. aureus vaccineAureus vaccineClinical efficacyMRSA isolatesImmune cellsOpsonophagocytic killingFrequent causeImmune responseHost immunityHost prothrombinProtective antigenSpecific antibodiesInfectionSurface moleculesAntibodiesS. aureusStaphylococcus aureusAntibody therapeuticsStaphylococcal surface
2012
Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus
McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus. Infection And Immunity 2012, 80: 3389-3398. PMID: 22825443, PMCID: PMC3457572, DOI: 10.1128/iai.00562-12.Peer-Reviewed Original ResearchStaphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections
McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFormation of abscessesDrug-resistant S. aureusHost immune cellsHospital-acquired infectionsFactor binding proteinInnate defense mechanismsVon Willebrand factorThromboembolic lesionsClotting of plasmaPreclinical evidenceLethal sepsisImmune cellsStaphylococcal infectionsDisease pathogenesisCoagulation productsClinical isolatesCurrent epidemicKey innate defence mechanismCoagulation cascadeStaphylococcal productsInfectionWillebrand factorOpsonophagocytic clearanceHost infectionFibrin meshwork
2010
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 2010, 28: 6382-6392. PMID: 20226248, PMCID: PMC3095377, DOI: 10.1016/j.vaccine.2010.02.097.Peer-Reviewed Original ResearchConceptsIntravenous challengeAbscess formationStaphylococcus aureus abscess formationLethal intravenous challengePathogenesis of infectionHospital-acquired infectionsStaphylococcal abscess formationNaïve miceActive immunizationLethal challengeSurface proteinsOpsonophagocytic killingStaphylococcal diseaseFrequent causeSubunit vaccineExperimental animalsMouse bloodAntibodiesStaphylococcus aureusBind hemoglobinVaccineInfectionMiceStaphylococciBacteremia