2007
Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection
de Faria M, Athanazio DA, Ramos E, Silva EF, Reis MG, Ko AI. Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection. Journal Of Comparative Pathology 2007, 137: 231-238. PMID: 17996544, DOI: 10.1016/j.jcpa.2007.08.001.Peer-Reviewed Original ResearchConceptsInterstitial nephritisPathology of leptospirosisKidneys of ratsMorphological alterationsPathogenesis of leptospirosisFiocruz L1-130Leptospiral diseaseWistar ratsLeptospira infectionPathological changesUrban outbreaksRecreational exposureHuman infectionsL1-130RatsWidespread anthropozoonosisKidneyLeptospira interrogansLeptospirosisNephritisInfectionDiseaseEmergent diseaseMammalian reservoirsHost resistance
1999
Urban epidemic of severe leptospirosis in Brazil
Ko A, Reis M, Dourado C, Johnson W, Riley L, Group S. Urban epidemic of severe leptospirosis in Brazil. The Lancet 1999, 354: 820-825. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.Peer-Reviewed Original ResearchConceptsDengue feverInfectious disease referral hospitalAggressive supportive careEpidemic of leptospirosisStrong independent predictorPositive blood culturesLarge urban outbreaksIdentification of leptospiresRenal insufficiencyRespiratory insufficiencySevere leptospirosisSupportive careIndependent predictorsReferral hospitalOutpatient clinicSevere anemiaSevere manifestationsActive surveillanceMental statusRisk factorsBlood culturesDiagnostic confusionUrban epidemicMicroagglutination testUrban outbreaks