2021
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2015
Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review
Zaky A, Zeliadt SB, Treggiari MM. Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review. Anaesthesia And Intensive Care 2015, 43: 23-33. PMID: 25579286, DOI: 10.1177/0310057x1504300105.Peer-Reviewed Original ResearchConceptsPatient-level interventionsIntensive care unitMDR-GNBCare unitSystematic reviewMultidrug-resistant Gram-negative bacterial infectionsSelective digestive decontaminationComparative interventional studyGram-negative bacterial infectionsInfection control effortsResistant Gram-negative bacteriaRate of infectionPrevention of colonisationDigestive decontaminationInterventional trialsIll patientsInterventional studyAnalysed trialsControl groupBacterial infectionsInfectionInterventionTrialsSignificant reductionScience databases
2013
A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients
Dale CR, Bryson CL, Fan VS, Maynard C, Yanez ND, Treggiari MM. A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients. Critical Care Medicine 2013, 41: 2610-2617. PMID: 23989171, DOI: 10.1097/ccm.0b013e31829a6ee7.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsMechanical ventilationSurgery patientsCardiac surgeryAverage durationMean durationOrder setsCardiac surgery hospitalCardiovascular surgery patientsDelivery of analgesiaRetrospective cohort studyMultivariable linear regression modelsImproved patient outcomesShorter mean durationNon-federal hospitalsQuality scoresWashington State hospitalsShorter average durationHospital painCohort studyGreater analgesiaHospital factorsPatient factorsDelirium careSurgery HospitalEtomidate, Adrenal Function, and Mortality in Critically Ill Patients
Sunshine JE, Deem S, Weiss NS, Yanez ND, Daniel S, Keech K, Brown M, Treggiari MM. Etomidate, Adrenal Function, and Mortality in Critically Ill Patients. Respiratory Care 2013, 58: 639-646. PMID: 22906838, PMCID: PMC4126750, DOI: 10.4187/respcare.01956.Peer-Reviewed Original ResearchConceptsCritical illness-related corticosteroid insufficiencyIll patientsCorticosteroid insufficiencyHospital mortalityAdrenal functionInduction agentAdrenal function testingPrevious randomized studyRole of etomidateRetrospective cohort studyBaseline illness severityRisk of deathAlternative induction agentHigh-risk populationRisk of mortalitySmall randomized trialsAcademic medical centerNumber of deathsEtomidate administrationEtomidate exposureAdjusted riskCohort studySecondary outcomesOverall mortalityPrimary outcome
2012
Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults
Menon N, Joffe AM, Deem S, Yanez ND, Grabinsky A, Dagal AH, Daniel S, Treggiari MM. Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults. Respiratory Care 2012, 57: 1555-1563. PMID: 22324979, DOI: 10.4187/respcare.01617.Peer-Reviewed Original ResearchConceptsDifficult airwayHigh mortalityHospital stayAdmission severity scoresIll adult patientsComplications of intubationAirway management techniquesHospital mortalityInitial intubationMedian ICURespiratory failureTracheal extubationAdult patientsBaseline characteristicsCohort studyIll adultsIll patientsTracheal reintubationDifficult intubationSeverity scoreSubsequent intubationRisk factorsPatient costsReintubationRelative oddsSedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation.
Karir V, Hough CL, Daniel S, Caldwell E, Treggiari MM. Sedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation. Minerva Anestesiologica 2012, 78: 801-9. PMID: 22475804.Peer-Reviewed Original ResearchConceptsCumulative doseMorphine equivalentsIll patientsMechanical ventilationSubstance abuseDecreased opioid useLow cumulative doseRetrospective cohort studyHigh cumulative dosesMajority of patientsAmount of sedativesPatient-specific factorsUse of sedativesLess frequent useLorazepam equivalentsSedative needsAdult patientsCohort studyOpioid usePatient characteristicsOpioid analgesicsCumulative dosesEthanol abuseSedation practicesAlcohol abuse
2011
Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury
Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD. Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. Journal Of Critical Care 2011, 26: 144-151. PMID: 20869200, DOI: 10.1016/j.jcrc.2010.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAdolescentAdultAgedAged, 80 and overAPACHECritical IllnessFemaleGuideline AdherenceHospital MortalityHumansInjury Severity ScoreIntraoperative PeriodLength of StayMaleMiddle AgedPositive-Pressure RespirationPractice Guidelines as TopicRetrospective StudiesRisk FactorsTidal VolumeYoung AdultConceptsAcute respiratory distress syndromeAcute lung injuryALI/acute respiratory distress syndromeLTV ventilationLung injuryClinical outcomesLow tidal volume ventilation strategyALI/ARDS diagnosisLow tidal volume ventilationVolume ventilation strategyRespiratory distress syndromeTidal volume ventilationARDS diagnosisHospital mortalityIntraoperative adherenceHospital lengthSecondary outcomesSurgical patientsDistress syndromeIll patientsVolume ventilationImproved oxygenationPatient outcomesRetrospective analysisMAIN OUTCOME
2009
Randomized trial of light versus deep sedation on mental health after critical illness*
Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, Heidegger CP, Weiss NS. Randomized trial of light versus deep sedation on mental health after critical illness*. Critical Care Medicine 2009, 37: 2527-2534. PMID: 19602975, DOI: 10.1097/ccm.0b013e3181a5689f.Peer-Reviewed Original ResearchConceptsDeep sedation groupIntensive care unit dischargeIntensive care unitPosttraumatic stress disorderPatients' mental healthSedation groupDeep sedationCare unitMechanical ventilationStress disorderMental healthIntensive care unit staySingle tertiary care centerLight sedation groupDuration of ventilationTertiary care centerUnit dischargeOccurrence of anxietyTrials of lightPosttraumatic stress disorder (PTSD) symptomsUnit stayAdult patientsAdverse eventsCritical illnessPrimary outcome
2004
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*
Treggiari MM, Hudson LD, Martin DP, Weiss NS, Caldwell E, Rubenfeld G. Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*. Critical Care Medicine 2004, 32: 327-331. PMID: 14758144, DOI: 10.1097/01.ccm.0000108870.09693.42.Peer-Reviewed Original ResearchConceptsALI/acute respiratory distress syndromeAcute respiratory distress syndromeAcute lung injuryAcute Physiology ScoreRespiratory distress syndromeTrauma patientsHospital mortalityPhysiology ScoreLung injuryDistress syndromeSeverity scoreHospital costsTrauma severityAmerican-European Consensus Conference definitionPresence of ALIIntensive care unit admissionIntensive care unit stayIll trauma patientsCare unit admissionInjury Severity ScoreConsensus Conference definitionLevel I centersCrude relative riskIntensive care unitLength of stay