2024
Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Kelly-Hedrick M, Liu S, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Journal Of Intensive Care Medicine 2024, 39: 875-882. PMID: 38449336, DOI: 10.1177/08850666241236724.Peer-Reviewed Original ResearchAssociated with hospital mortalityRetrospective cohort studyLength of stayModerate-severe TBITraumatic brain injuryCohort studyIntensive care unitBeta-blocker classHospital mortalityUtilization patternsClaims-based datasetHospital length of stayIll patientsCritically ill patientsIntensive care unit length of stayBrain injuryBeta-blockersHealthcare databasesInclusion criteriaSecondary outcomesPremier Healthcare DatabasePrimary outcomeVasopressor utilizationIntensive care unit stayHospitalAssociation of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Liu S, Kelly-Hedrick M, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Anesthesia & Analgesia 2024, 139: 366-374. PMID: 38335145, PMCID: PMC11250935, DOI: 10.1213/ane.0000000000006869.Peer-Reviewed Original ResearchLength of stayTraumatic brain injuryImprove patient outcomesModerate-severe TBIRetrospective cohort studyMechanical ventilationMechanically ventilated patientsDexmedetomidine exposureDay of admissionCohort studyHospital mortalityOdds of hospital mortalityPatient outcomesAssociated with reduced oddsCohort of critically ill adult patientsPrimary outcome of hospital mortalityReduce length of stayHospital costsAssociated with oddsOutcome of hospital mortalityCritically ill adult patientsDay of ICU admissionHospital length of stayIll adult patientsPublic health problem
2021
Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample
Bardia A, Treggiari MM, Michel G, Dai F, Tickoo M, Wai M, Schuster K, Mathis M, Shah N, Kheterpal S, Schonberger RB. Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample. JAMA Network Open 2021, 4: e2137296. PMID: 34905007, PMCID: PMC8672234, DOI: 10.1001/jamanetworkopen.2021.37296.Peer-Reviewed Original ResearchConceptsSurgical site infectionAntibiotic prophylaxis guidelinesWeight-adjusted dosingInfectious Diseases SocietyAntibiotic choiceProphylaxis guidelinesCohort studyDiseases SocietyOverall adherenceFuture quality improvement effortsStudy periodAntibiotic administration guidelinesPrimary end pointTiming of administrationGynecological surgical proceduresQuality improvement effortsIntraoperative antibioticsOverall nonadherenceNoncardiac surgeryAdult patientsEmergency surgeryFirst doseGuideline adherenceSurgical encountersAmerica guidelinesTreatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2020
Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults.
Tiwary N, Treggiari MM, Yanez ND, Kirsch JR, Tekkali P, Taylor CC, Schenning KJ. Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults. Anesthesia & Analgesia 2020, 132: 1112-1119. PMID: 33002933, DOI: 10.1213/ane.0000000000005197.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia Recovery PeriodAnesthesia, GeneralCognitionCognitive DysfunctionElective Surgical ProceduresEmergence DeliriumFemaleHumansMaleMental Status and Dementia TestsPredictive Value of TestsPreoperative CareReproducibility of ResultsRisk AssessmentRisk FactorsTreatment OutcomeConceptsPostanesthesia care unitMini-Cog scorePACU deliriumDay of surgeryTimes higher oddsNormal cognitive functionCohort studyCognitive impairmentMini-CogPostoperative deliriumCognitive functionPreoperative clinicHigher oddsPatients meeting eligibility criteriaPostanesthesia Care Unit DeliriumShort Confusion Assessment MethodConfusion Assessment MethodOlder surgical patientsProspective cohort studyAnesthesiologists physical statusMultivariable logistic regressionMeeting eligibility criteriaSubjective memory impairmentOdds ratio analysisOlder patients
2019
Electromagnetic Interference with Protocolized Electrosurgery Dispersive Electrode Positioning in Patients with Implantable Cardioverter Defibrillators.
Schulman PM, Treggiari MM, Yanez ND, Henrikson CA, Jessel PM, Dewland TA, Merkel MJ, Sera V, Harukuni I, Anderson RB, Kahl E, Bingham A, Alkayed N, Stecker EC. Electromagnetic Interference with Protocolized Electrosurgery Dispersive Electrode Positioning in Patients with Implantable Cardioverter Defibrillators. Anesthesiology 2019, 130: 530-540. PMID: 30601218, DOI: 10.1097/aln.0000000000002571.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorCardiac surgeryNoncardiac surgeryCardioverter defibrillatorAntitachycardia therapyMonopolar electrosurgeryElectrode positioningInappropriate antitachycardia therapyProspective cohort studyHeart Rhythm SocietyExpert clinical opinionAcademic medical centerPaucity of dataCohort studyCurrent management recommendationsProtocolized ApproachMedical CenterClinical opinionSurgeryPatientsUmbilicusTherapyDefibrillatorDispersive electrodeAmerican Society
2018
Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit
Fink RJ, Young A, Yanez ND, Hom M, Mai J, Treggiari M, Merkel M. Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2018, 38: 1241-1249. PMID: 30403299, DOI: 10.1002/phar.2195.Peer-Reviewed Original ResearchConceptsIntensive care unitPostcardiac surgery patientsCardiovascular intensive care unitFluid resuscitation strategySurgery patientsCare unitCohort studySecondary outcomesAlbumin useResuscitation strategiesPost interventionAfter cohort studyPost-intervention periodPost-intervention time periodsNet cost savingsIntervention time periodFluid resuscitationClinical parametersAlbumin reductionEvidence-based practiceAdmission ordersIntervention periodLactated Ringer'sPatientsEducational interventionSurgical specialty and preoperative medical consultation based on commercial health insurance claims
Thilen SR, Woersching AL, Cornea AM, Lowy E, Weaver EM, Treggiari MM. Surgical specialty and preoperative medical consultation based on commercial health insurance claims. Perioperative Medicine 2018, 7: 9. PMID: 29755736, PMCID: PMC5935907, DOI: 10.1186/s13741-018-0089-4.Peer-Reviewed Original ResearchDeyo comorbidity indexSurgical riskPreoperative consultationSurgical specialtiesComorbidity indexGeneral surgeryCommercial health insurance claimsLow surgical risk patientsMethodsThis retrospective cohort studyHigh surgical riskIntermediate surgical riskLikelihood of consultationPreoperative medical consultationsSurgical risk patientsHigh-risk patientsLow-risk surgeryRetrospective cohort studyHealth insurance claimsConclusionsThe likelihoodMore comorbiditiesComorbidity burdenRisk patientsCohort studyLow comorbidityPreoperative evaluation
2015
Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study
Bhananker SM, Treggiari MM, Sellers BA, Cain KC, Ramaiah R, Thilen SR. Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study. Journal Canadien D'anesthésie 2015, 62: 1089-1096. PMID: 26224034, DOI: 10.1007/s12630-015-0433-9.Peer-Reviewed Original ResearchConceptsTOF-Watch SXTOF countNeuromuscular blockadeReversal agentsAnesthesia providersCohort studyTOF-WatchMethodsThis prospective observational cohort studyAnesthesiologists physical status IIIProspective observational cohort studyDose of rocuroniumObservational cohort studyProspective cohort studyComparison of TrainPremature administrationInadequate dosingElective surgeryBlockadeDoseAmerican SocietyPatientsCountSubjective assessmentProvidersLower counts
2014
Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals
Khandelwal N, Dale CR, Benkeser DC, Joffe AM, Yanez ND, Treggiari MM. Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 29: 551-559. PMID: 25802193, PMCID: PMC4427545, DOI: 10.1053/j.jvca.2014.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAirway ExtubationAirway ManagementCardiac Surgical ProceduresCohort StudiesCoronary Artery BypassCritical CareDatabases, FactualFemaleHealth SurveysHumansIntubation, IntratrachealMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic FactorsTreatment FailureTreatment OutcomeWashingtonConceptsIntensive care unitCardiac surgeryWashington State hospitalsNonfederal hospitalsState HospitalAcute care daysGreater hospital volumeOdds of reintubationCoronary artery bypassRetrospective cohort studyPatient-level characteristicsMultivariate logistic regressionSignificant heterogeneityValvular surgeryArtery bypassCohort studyHospital factorsHospital volumePatient characteristicsTracheal reintubationCare unitProcedure characteristicsHospital characteristicsCare daysReintubationPreoperative Consultations for Medicare Patients Undergoing Cataract Surgery
Thilen SR, Treggiari MM, Lange JM, Lowy E, Weaver EM, Wijeysundera DN. Preoperative Consultations for Medicare Patients Undergoing Cataract Surgery. JAMA Internal Medicine 2014, 174: 380-388. PMID: 24366269, PMCID: PMC4167873, DOI: 10.1001/jamainternmed.2013.13426.Peer-Reviewed Original ResearchConceptsPreoperative consultationCataract surgeryHierarchical logistic regression modelingPatients 66 yearsElective surgical proceduresLogistic regression modelingIndex surgeryCohort studyEntire cohortElective proceduresSurgical proceduresMAIN OUTCOMEMedicare beneficiariesSurgeryMedicare Part BAnesthesia providersNational random sampleUrban residenceTemporal trendsRegression modelingConsultationCohortFacility typeSuch consultationsClear guidelines
2013
A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients
Dale CR, Bryson CL, Fan VS, Maynard C, Yanez ND, Treggiari MM. A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients. Critical Care Medicine 2013, 41: 2610-2617. PMID: 23989171, DOI: 10.1097/ccm.0b013e31829a6ee7.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsMechanical ventilationSurgery patientsCardiac surgeryAverage durationMean durationOrder setsCardiac surgery hospitalCardiovascular surgery patientsDelivery of analgesiaRetrospective cohort studyMultivariable linear regression modelsImproved patient outcomesShorter mean durationNon-federal hospitalsQuality scoresWashington State hospitalsShorter average durationHospital painCohort studyGreater analgesiaHospital factorsPatient factorsDelirium careSurgery HospitalPredictors of Reintubation in Critically Ill Patients
Miu T, Joffe AM, Yanez ND, Khandelwal N, Dagal AH, Deem S, Treggiari MM. Predictors of Reintubation in Critically Ill Patients. Respiratory Care 2013, 59: 178-185. PMID: 23882103, DOI: 10.4187/respcare.02527.Peer-Reviewed Original ResearchConceptsAcute Physiology Score IIDiastolic blood pressureExtubation failureScore IIBlood pressureMinute ventilationAdmission Simplified Acute Physiology Score IISimplified Acute Physiology Score IIRapid shallow breathing indexMultivariable logistic regression analysisPredictors of reintubationTertiary care centerShallow breathing indexAdditional independent predictorsBivariate logistic regression modelLogistic regression analysisLogistic regression modelsICU extubationExtubation successICU admissionBaseline characteristicsCohort studyIll patientsIndependent predictorsBreathing indexPatterns of Preoperative Consultation and Surgical Specialty in an Integrated Healthcare System
Thilen SR, Bryson CL, Reid RJ, Wijeysundera DN, Weaver EM, Treggiari MM. Patterns of Preoperative Consultation and Surgical Specialty in an Integrated Healthcare System. Anesthesiology 2013, 118: 1028-1037. PMID: 23503373, PMCID: PMC4162741, DOI: 10.1097/aln.0b013e31828ea68a.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overCohort StudiesComorbidityDelivery of Health Care, IntegratedFemaleHealth Status IndicatorsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPractice Patterns, Physicians'Preoperative PeriodPrescription DrugsReferral and ConsultationRiskSpecialties, SurgicalSurgical Procedures, OperativeYoung AdultConceptsIntegrated healthcare systemPreoperative consultationSurgical specialtiesHealthcare systemDeyo comorbidity indexPreoperative medical consultationsCardiac Risk IndexCardiac risk scoreLow-risk surgeryLow cardiac riskGroup Health CooperativeSubstantial practice variationMultivariable logistic regressionComorbidity indexMedication classesCohort studyCardiac riskElective surgeryPotential confoundersPrescription medicationsHealth CooperativeOdds ratioPractice variationGeneral internistsFamily physiciansEtomidate, Adrenal Function, and Mortality in Critically Ill Patients
Sunshine JE, Deem S, Weiss NS, Yanez ND, Daniel S, Keech K, Brown M, Treggiari MM. Etomidate, Adrenal Function, and Mortality in Critically Ill Patients. Respiratory Care 2013, 58: 639-646. PMID: 22906838, PMCID: PMC4126750, DOI: 10.4187/respcare.01956.Peer-Reviewed Original ResearchConceptsCritical illness-related corticosteroid insufficiencyIll patientsCorticosteroid insufficiencyHospital mortalityAdrenal functionInduction agentAdrenal function testingPrevious randomized studyRole of etomidateRetrospective cohort studyBaseline illness severityRisk of deathAlternative induction agentHigh-risk populationRisk of mortalitySmall randomized trialsAcademic medical centerNumber of deathsEtomidate administrationEtomidate exposureAdjusted riskCohort studySecondary outcomesOverall mortalityPrimary outcome
2012
Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults
Menon N, Joffe AM, Deem S, Yanez ND, Grabinsky A, Dagal AH, Daniel S, Treggiari MM. Occurrence and Complications of Tracheal Reintubation in Critically Ill Adults. Respiratory Care 2012, 57: 1555-1563. PMID: 22324979, DOI: 10.4187/respcare.01617.Peer-Reviewed Original ResearchConceptsDifficult airwayHigh mortalityHospital stayAdmission severity scoresIll adult patientsComplications of intubationAirway management techniquesHospital mortalityInitial intubationMedian ICURespiratory failureTracheal extubationAdult patientsBaseline characteristicsCohort studyIll adultsIll patientsTracheal reintubationDifficult intubationSeverity scoreSubsequent intubationRisk factorsPatient costsReintubationRelative oddsSedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation.
Karir V, Hough CL, Daniel S, Caldwell E, Treggiari MM. Sedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation. Minerva Anestesiologica 2012, 78: 801-9. PMID: 22475804.Peer-Reviewed Original ResearchConceptsCumulative doseMorphine equivalentsIll patientsMechanical ventilationSubstance abuseDecreased opioid useLow cumulative doseRetrospective cohort studyHigh cumulative dosesMajority of patientsAmount of sedativesPatient-specific factorsUse of sedativesLess frequent useLorazepam equivalentsSedative needsAdult patientsCohort studyOpioid usePatient characteristicsOpioid analgesicsCumulative dosesEthanol abuseSedation practicesAlcohol abuse
2009
Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.
Martini RP, Deem S, Yanez ND, Chesnut RM, Weiss NS, Daniel S, Souter M, Treggiari MM. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. Journal Of Neurosurgery 2009, 111: 644-9. PMID: 19392603, DOI: 10.3171/2009.2.jns08998.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCohort StudiesFemaleHealth ResourcesHospital CostsHospital MortalityHumansIntracranial PressureLength of StayMaleMiddle AgedMonitoring, PhysiologicOxygenPrognosisRegression AnalysisRespiration, ArtificialRetrospective StudiesTrauma Severity IndicesTreatment OutcomeConceptsBrain tissue oxygen monitoringHospital mortality rateTissue oxygen monitoringTraumatic brain injurySevere traumatic brain injuryMortality rateBrain injuryHospital lengthNeurological outcomeHospital dischargeClinical managementICP monitoringMedian hospital lengthWorse neurological outcomeHospital resource utilizationOxygen monitoringMain outcome measuresFunctional Independence ScoreIntracranial pressure monitoringSeverity of injuryBaseline characteristicsCohort studyPatient ageMore patientsOsmotic therapyAtrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome
Treggiari MM, Bendjelid K, Yanez ND, Heidegger CP, Suter PM, Romand JA. Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Journal Of Critical Care 2009, 25: 23-29. PMID: 19327320, DOI: 10.1016/j.jcrc.2008.10.014.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAtrial natriuretic peptideBaseline atrial natriuretic peptideRespiratory distress syndromeNT-proNatriuretic peptideBNP concentrationsDistress syndromeCardiac peptidesHigh atrial natriuretic peptideBrain natriuretic peptide concentrationsB-type natriuretic peptideNitric oxideCyclic guanosine monophosphate concentrationBaseline NT-proProspective cohort studyNatriuretic peptide concentrationsSubgroup of patientsCardiac natriuretic peptidesGuanosine monophosphate concentrationCyclic guanosine monophosphateIntrapulmonary shuntCohort studyConsecutive patientsClinical benefitEarly anti-pseudomonal acquisition in young patients with cystic fibrosis: Rationale and design of the EPIC clinical trial and observational study,
Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA, Ramsey BW, Group E. Early anti-pseudomonal acquisition in young patients with cystic fibrosis: Rationale and design of the EPIC clinical trial and observational study,. Contemporary Clinical Trials 2009, 30: 256-268. PMID: 19470318, PMCID: PMC2783320, DOI: 10.1016/j.cct.2009.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnti-Bacterial AgentsChildChild, PreschoolCiprofloxacinCohort StudiesCystic FibrosisDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansInfantLongitudinal StudiesMalePseudomonas aeruginosaPseudomonas InfectionsRisk FactorsTobramycinTreatment OutcomeConceptsEarly Pa infectionYoung CF patientsRespiratory culturesRisk factorsCystic fibrosisCohort studyPA infectionClinical trialsObservational studyCF patientsEarly CF lung diseaseProgressive obstructive pulmonary diseaseProportion of patientsClinical efficacy dataObstructive pulmonary diseasePositive respiratory culturesPatients ages 1Longitudinal cohort studyCF lung diseaseChronic endobronchial infectionInfection control programPa acquisitionPA-negative patientsOral ciprofloxacinOral placebo