2007
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 2007, 10: 376-384. PMID: 17277774, DOI: 10.1038/nn1846.Peer-Reviewed Original ResearchAction PotentialsAnalysis of VarianceAnimalsBehavior, AnimalCyclic AMPDopamine AgentsDose-Response Relationship, DrugDrug InteractionsIontophoresisMacaca mulattaMaleMaze LearningMemory, Short-TermNeuronsNeuropsychological TestsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, Dopamine D1Sensitivity and SpecificityThionucleotides
2004
Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory. Science 2004, 306: 882-884. PMID: 15514161, DOI: 10.1126/science.1100021.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAlkaloidsAnimalsBenzophenanthridinesCarbolinesElectrophysiologyEnzyme ActivationFemaleImidazolesLithium CarbonateMacaca mulattaMaleMemoryNeuronsPhenanthridinesPrefrontal CortexProtein Kinase CRatsRats, Sprague-DawleyReceptors, Adrenergic, alpha-1Signal TransductionStress, PhysiologicalTetradecanoylphorbol AcetateValproic AcidConceptsPrefrontal cortical regulationPrefrontal cortexPrefrontal cortical cognitive functionCortical regulationCortical cognitive functionsPrefrontal cortical dysfunctionWorking memoryElectrophysiological measuresCognitive functionRepresentational knowledgeThought disorderImpaired judgmentBrain regionsStress exposureMemoryCortical dysfunctionHigher brain regionsCortexThoughtDistractibilityEmotionsImpulsivityHigh levelsJudgmentsBehavior