2023
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID
Zadeh A, Arnsten A, Wang M. Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID. Neurology International 2023, 15: 725-742. PMID: 37368329, PMCID: PMC10303664, DOI: 10.3390/neurolint15020045.Peer-Reviewed Original ResearchLong COVIDGlutamate carboxypeptidase IIKynurenic acidNicotinic alpha 7 receptorCognitive deficitsProduction of KYNACOVID-19 infectionDorsolateral prefrontal cortexAgonist guanfacineNeuronal firingCognitive symptomsAcetyl cysteineCognitive functionPrefrontal cortexScientific rationaleCarboxypeptidase IIPFC functionCOVIDDeficitsReceptorsTreatmentExecutive functioningNMDAGuanfacineNeurotransmission
2013
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 12078-12083. PMID: 23818597, PMCID: PMC3718126, DOI: 10.1073/pnas.1307849110.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAconitineAlpha7 Nicotinic Acetylcholine ReceptorAnalysis of VarianceAnimalsBridged Bicyclo Compounds, HeterocyclicCholinergic AgonistsCholinergic AntagonistsCognitionFemaleIontophoresisMacaca mulattaMaleMecamylamineMicroscopy, ImmunoelectronN-MethylaspartatePhenolsPiperidinesPrefrontal CortexQuinuclidinesReceptors, NicotinicSpatial BehaviorSynapsesVisual PerceptionConceptsDorsolateral prefrontal cortexΑ7 nAChRsPrefrontal cortexΑ7 nicotinic acetylcholine receptorGlutamatergic NMDA receptorsCognitive circuitsNicotinic α7 receptorsPrimary visual cortexNMDA receptor actionGenetic insultsNicotinic acetylcholine receptorsDlPFC circuitsPrimate dlPFCACh depletionNMDA actionNMDA receptorsPyramidal cellsΑ7 receptorsNeuronal firingNAChR blockadeAcetylcholine receptorsVisual cortexPersistent firingCognitive functionLow-dose stimulation
2010
Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors
Gamo NJ, Wang M, Arnsten AF. Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1011-1023. PMID: 20855046, PMCID: PMC2999884, DOI: 10.1016/j.jaac.2010.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAnimalsAppetitive BehaviorAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrain MappingCentral Nervous System StimulantsChildDisease Models, AnimalDose-Response Relationship, DrugFemaleHumansMacaca mulattaMaleMemory, Short-TermMethylphenidateNerve NetOrientationPrefrontal CortexPropylaminesPyramidal CellsReceptors, Adrenergic, alpha-2Receptors, Dopamine D1SaccadesConceptsAttention-deficit/hyperactivity disorder treatmentOptimal dosesPFC cognitive functionDopamine receptor antagonistDopamine D1 receptorsAttention-deficit/hyperactivity disorderAdrenoceptor antagonistPrefrontal cortex functionΑ2-adrenergicCellular levelReceptor antagonistD1 receptorsDopamine receptorsTherapeutic effectReceptor mechanismsSCH23390Moderate dosesAtomoxetineIndirect stimulationDisorder treatmentHigh dosesCortex functionPersistent firingCognitive functionReceptor action
2009
5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates
Arnsten A, Vijayraghavan S, Wang M, Gamo N, Paspalas C. 5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates. 2009, 230-248. DOI: 10.1093/acprof:oso/9780195373035.003.0016.Peer-Reviewed Original Research
2004
Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory. Science 2004, 306: 882-884. PMID: 15514161, DOI: 10.1126/science.1100021.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAlkaloidsAnimalsBenzophenanthridinesCarbolinesElectrophysiologyEnzyme ActivationFemaleImidazolesLithium CarbonateMacaca mulattaMaleMemoryNeuronsPhenanthridinesPrefrontal CortexProtein Kinase CRatsRats, Sprague-DawleyReceptors, Adrenergic, alpha-1Signal TransductionStress, PhysiologicalTetradecanoylphorbol AcetateValproic AcidConceptsPrefrontal cortical regulationPrefrontal cortexPrefrontal cortical cognitive functionCortical regulationCortical cognitive functionsPrefrontal cortical dysfunctionWorking memoryElectrophysiological measuresCognitive functionRepresentational knowledgeThought disorderImpaired judgmentBrain regionsStress exposureMemoryCortical dysfunctionHigher brain regionsCortexThoughtDistractibilityEmotionsImpulsivityHigh levelsJudgmentsBehavior