1999
Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes.
Bektas A, Warram J, White M, Krolewski A, Doria A. Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes 1999, 48: 640-642. PMID: 10078569, DOI: 10.2337/diabetes.48.3.640.Peer-Reviewed Original ResearchAdultAge of OnsetChromosome MappingChromosomes, Human, Pair 13Diabetes Mellitus, Type 2Diabetes, GestationalFemaleGenes, DominantGenetic LinkageGenetic MarkersGlucose IntoleranceHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLod ScoreMalePhosphoproteinsPregnancyReceptor, InsulinReference Values
1998
Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role
Kalidas K, Wasson J, Glaser B, Meyer J, Duprat L, White M, Permutt M. Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role. Diabetologia 1998, 41: 1389-1391. PMID: 9833949, DOI: 10.1007/s001250051081.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChromosome MappingChromosomes, Human, Pair 13Diabetes Mellitus, Type 1Europe, EasternGenetic Carrier ScreeningGenetic LinkageGenetic MarkersGenotypeHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsJewsMiceMicrosatellite RepeatsPhosphoproteinsPolymorphism, GeneticStatistics, NonparametricConceptsIRS-2 geneRadiation hybrid panel mappingPolymorphic markersInsulin receptor substrate 2Nonparametric linkage analysisMap positionChromosome 13q34Evidence of linkageInsulin receptor substrate-2 (IRS-2) geneGene regionLinkage analysisGenesSubstrate 2Excess alleleInsulin receptorNearby markersType II diabetesAshkenazi Jewish familiesMice resultsII diabetesSusceptibility roleMarkersFamilyPeripheral insulin resistance
1997
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Sun X, Pons S, Wang L, Zhang Y, Yenush L, Burks D, Myers M, Glasheen E, Copeland N, Jenkins N, Pierce J, White M. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Endocrinology 1997, 11: 251-62. PMID: 9013772, DOI: 10.1210/mend.11.2.9885.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAmino Acid SequenceAnimalsBase SequenceCell DifferentiationCells, CulturedChromosome MappingChromosomesCytokinesInsulinInsulin Receptor Substrate ProteinsInterleukin-4Intracellular Signaling Peptides and ProteinsMiceMolecular Sequence DataPhosphoproteinsPhosphorylationSequence Homology, Amino AcidSignal TransductionTissue DistributionTyrosineConceptsMurine chromosome 8IRS-2IRS-1IRS-2 geneIRS proteinsExpression patternsSrc homology 2 domainChromosome 8Recombinant SH2 domainsSpecific expression patternsMurine chromosome 1Amino acid sequenceDifferential tyrosine phosphorylationMurine hematopoietic cellsDistinct phosphorylation patternsSH2 domainSignal transductionSingle exonPhosphorylation patternTyrosine phosphorylationIL-4 stimulationAcid sequenceChromosome 1Signaling adapterCytokine signaling