2013
Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy
Hookham M, O'Donovan H, Church R, Mercier‐Zuber A, Luzi L, Curran S, Carew R, Droguett A, Mezzano S, Schubert M, White M, Crean J, Brazil D. Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy. The FEBS Journal 2013, 280: 3232-3243. PMID: 23617393, PMCID: PMC4022317, DOI: 10.1111/febs.12305.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsBase SequenceBinding SitesBone Morphogenetic Protein 7Case-Control StudiesCell LineChildDiabetic NephropathiesEpitheliumFemaleGene ExpressionHumansInsulin Receptor Substrate ProteinsKidney TubulesMaleMiceMiddle AgedPhosphorylationProtein Processing, Post-TranslationalSignal TransductionSmad4 ProteinTranscriptional ActivationYoung AdultConceptsDiabetic nephropathyBone morphogenetic protein-7DN patientsInsulin receptor substrateChronic kidney disease severityEnd-stage renal diseaseProgression of DNKidney epitheliumTyrosine/serine phosphorylationHuman kidney proximal tubule epithelial cellsKidney disease severityProximal tubule epithelial cellsKidney proximal tubule epithelial cellsHK-2 cellsRole of insulinInsulin receptor substrate 2Growth factor-β1Tubule epithelial cellsIRS2 transcriptionSDS/PAGEIRS proteinsDN progressionRenal diseaseKidney failureMorphogenetic protein-7
2012
Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review
Behl M, Rao D, Aagaard K, Davidson T, Levin E, Slotkin T, Srinivasan S, Wallinga D, White M, Walker V, Thayer K, Holloway A. Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review. Environmental Health Perspectives 2012, 121: 170-180. PMID: 23232494, PMCID: PMC3569686, DOI: 10.1289/ehp.1205404.Peer-Reviewed Original ResearchConceptsMaternal smokingChildhood obesityMetabolic disordersRisk factorsChildhood overweight/obesityUnmeasured residual confoundingOverweight/obesityRisk of obesityCurrent epidemiological dataType 2 diabetesPotential risk factorsType 1 diabetesEarly life exposureEnvironmental chemicalsExperimental animal studiesPerinatal exposureMetabolic syndromeNicotine exposureMetabolic outcomesResidual confoundingEpidemiological dataCigarette smokeObesitySmokingAnimal studies