2008
Irs2 Inactivation Suppresses Tumor Progression in Pten +/− Mice
Szabolcs M, Keniry M, Simpson L, Reid L, Koujak S, Schiff S, Davidian G, Licata S, Gruvberger-Saal S, Murty V, Nandula S, Efstratiadis A, Kushner J, White M, Parsons R. Irs2 Inactivation Suppresses Tumor Progression in Pten +/− Mice. American Journal Of Pathology 2008, 174: 276-286. PMID: 19095950, PMCID: PMC2631340, DOI: 10.2353/ajpath.2009.080086.Peer-Reviewed Original ResearchConceptsPI3KInsulin receptor substrate-2 expressionProstatic intraepithelial neoplasiaHuman prostate cancerCancer cell growthSuppresses tumor progressionIntraepithelial neoplasiaInitiation of neoplasiaProstate cancerIRS2 expressionMultiple organsExpression of MYCTumor progressionTumor samplesMiceHuman cancersMYC expressionProgressionExpression levelsPTEN levelsBasement membraneIRS2NeoplasiaTumorsCancer
1997
Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin
Mendez R, Kollmorgen G, White M, Rhoads R. Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin. Molecular And Cellular Biology 1997, 17: 5184-5192. PMID: 9271396, PMCID: PMC232369, DOI: 10.1128/mcb.17.9.5184.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCalcium-Calmodulin-Dependent Protein KinasesEnzyme ActivationInsulinInsulin Receptor Substrate ProteinsMiceOligonucleotides, AntisensePhosphatidylinositol 3-KinasesPhosphoproteinsPhosphotransferases (Alcohol Group Acceptor)Protein BiosynthesisProtein Kinase CProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mycRibosomal Protein S6 KinasesConceptsGeneral protein synthesisPKC-zetaCell cycle progressionProtein synthesisIRS-1Insulin receptorCycle progressionGuanine nucleotide exchange factorsNucleotide exchange factorsInsulin-stimulated protein synthesisProto-oncogene AktTarget of rapamycinMitogen-activated protein kinaseInsulin-stimulated activationPKC zeta activationProtein kinase CζGrowth-regulating proteinsActive PKC-zetaPrevention of apoptosisExchange factorPhosphorylated substratesS6 kinaseProtein kinaseGab-1Ectopic expression