2008
Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
Wu J, Tseng Y, Xu C, Neubert T, White M, Hubbard S. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature Structural & Molecular Biology 2008, 15: 251-258. PMID: 18278056, DOI: 10.1038/nsmb.1388.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCHO CellsCricetinaeCricetulusCrystallography, X-RayHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsMiceModels, MolecularMolecular Sequence DataMutationPhosphoproteinsPhosphorylationPhosphotyrosineProtein BindingProtein Structure, TertiaryProtein-Tyrosine KinasesReceptor, IGF Type 1Structure-Activity RelationshipSubstrate SpecificityConceptsInsulin receptorPleckstrin homology domainCrucial adaptor proteinTwo-hybrid studiesInsulin receptor kinaseKinase active siteInsulin receptor substrate 2C-terminal regionTyrosine kinase domainPrevious yeastThreonine phosphorylationHomology domainAdaptor proteinReceptor kinaseKinase domainTyrosine phosphorylationBiochemical characterizationRegion functionsSubstrate 2Binding regionsPhosphorylationKinase inhibitionFactor 1IRS2Insulin-like growth factor-1
1991
The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction
Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce J, Bottaro D, White M, Di Fiore P. The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction. Molecular And Cellular Biology 1991, 11: 3191-3202. DOI: 10.1128/mcb.11.6.3191-3202.1991.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignal transductionSpecificity of substrate recognitionErbB-2Specificity of signal transductionAmino-terminal halfDeletion of residuesMitogenic signaling pathwaysMitogenic signal transductionEGFR kinaseGrowth factor receptorSubstrate recognitionTyrosine kinase domainJuxtamembrane regionKinase domainStructural homologyKinase propertiesFactor receptorMutation analysisSignaling pathwayTyrosine kinaseChimeric moleculesKinaseTyrosineTransduction