2016
Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice
Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed J, Khattabi I, Bonner-Weir S, Weir G, Sharma A, White M. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight 2016, 1: e80749. PMID: 27152363, PMCID: PMC4854304, DOI: 10.1172/jci.insight.80749.Peer-Reviewed Original ResearchInsulin receptor substrate 2Progression of diabetesΒ-cell growthHuman isletsΒ-cellsHuman islet transplantsIsolated human pancreatic isletsAdverse systemic effectsFirst-generation antihistaminesHistamine H1 receptorsΒ-cell replicationPancreatic β-cell growthAnti-CD3 AbPancreatic β-cellsHuman pancreatic isletsNuclear Pdx1NOD miceIslet transplantsDiabetic miceCell growthH1 receptorsIslet massIRS2 expressionDownstream signaling cascadesGlucose homeostasis
2009
Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice
Norquay L, D'Aquino K, Opare-Addo L, Kuznetsova A, Haas M, Bluestone J, White M. Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice. Endocrinology 2009, 150: 4531-4540. PMID: 19574401, PMCID: PMC2754683, DOI: 10.1210/en.2009-0395.Peer-Reviewed Original ResearchConceptsNonobese diabetic (NOD) miceBeta-cell destructionNOD miceInsulin receptor substrate 2Glucose toleranceDiabetes incidenceDiabetic miceIslet massAnti-CD3 antibody injectionNondiabetic NOD miceReduced diabetes incidenceRisk of diabetesBeta-cell massType 1 diabetesBetter glucose toleranceAnti-CD3 antibodyBeta-cell growthWk of ageDiabetic NODSevere insulitisOvert diabetesSubstrate 2C57BL/6 miceBeta-cell mitogenesisAntibody injection