2021
Irs2 deficiency alters hippocampus-associated behaviors during young adulthood
Tanokashira D, Wang W, Maruyama M, Kuroiwa C, White M, Taguchi A. Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. Biochemical And Biophysical Research Communications 2021, 559: 148-154. PMID: 33940386, PMCID: PMC8361845, DOI: 10.1016/j.bbrc.2021.04.101.Peer-Reviewed Original ResearchConceptsYoung adult male miceAdult male miceMale miceAlzheimer's diseaseType 2 diabetes mellitusInsulin-like growth factor-1Brain energy metabolismGrowth factor-1Young adult malesCore body temperatureDiabetes mellitusInsulin resistanceInsulin/insulin-like growth factor-1Risk factorsBehavioral alterationsCognitive impairmentGenetic backgroundPremature deathHippocampusMiceYoung adulthoodAberrant alterationsFactor 1Abnormal changesBody temperature
2011
Mechanisms of Insulin Action
White M, White M. Mechanisms of Insulin Action. 2011, 19-38. DOI: 10.1007/978-1-4614-1028-7_2.Peer-Reviewed Original ResearchInsulin-like growth factor 2Receptor tyrosine kinasesTyrosine kinaseInsulin-like signalingInsulin-like peptidesG protein-coupled receptorsInsulin-like growth factor-1Caenorhabditis elegansEnvironmental signalsHuman genomeFruit flyRelease of nutrientsGrowth factor 2Factor 1Factor 2Somatic growthKinaseLower animalsGrowth factor-1Common mechanismSimilar peptidesInsulin actionWide arrayMetabolismMetazoans
2001
Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2*
Rui L, Fisher T, Thomas J, White M. Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2*. Journal Of Biological Chemistry 2001, 276: 40362-40367. PMID: 11546773, DOI: 10.1074/jbc.m105332200.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsCarcinoma, HepatocellularDiabetes Mellitus, Type 2Down-RegulationFeedbackFibroblastsHumansInsulinInsulin Receptor Substrate ProteinsInsulin-Like Growth Factor IIntracellular Signaling Peptides and ProteinsLiver Neoplasms, ExperimentalMiceMitogen-Activated Protein KinasesOsmotic PressurePeptide HydrolasesPhosphatidylinositol 3-KinasesPhosphoproteinsProteasome Endopeptidase ComplexProtein KinasesProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktReceptor, InsulinSignal TransductionTOR Serine-Threonine KinasesTumor Cells, CulturedUbiquitinConceptsInsulin-like growth factor-1Insulin/IGFMouse embryo fibroblastsProteasome-mediated degradationIRS-2Embryo fibroblastsInsulin/insulin-like growth factor-1 signalingInsulin receptor substrate (IRS) proteinsUbiquitin/proteasome-mediated degradationNovel negative feedback mechanismInsulin-like growth factor-1 signalingInsulin receptor substrate 2Inhibitor of phosphatidylinositolIRS-1 activationPeripheral insulin actionIGF-1 treatmentReceptor tyrosine kinasesHomologous receptor tyrosine kinasesGrowth factor-1IRS proteinsSubstrate proteinsBeta-cell survivalOsmotic stressTyrosine kinaseIRS-1
2000
IRS-2 pathways integrate female reproduction and energy homeostasis
Burks D, de Mora J, Schubert M, Withers D, Myers M, Towery H, Altamuro S, Flint C, White M. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000, 407: 377-382. PMID: 11014193, DOI: 10.1038/35030105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnergy IntakeEnergy MetabolismEstrusFemaleFertilityGonadal Steroid HormonesHomeostasisInfertilityInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLeptinLuteinizing HormoneMaleMiceMice, Inbred C57BLMice, KnockoutOvaryPhosphoproteinsPituitary GlandReceptor, InsulinReproductionSignal TransductionSteroidsConceptsInsulin receptor substrate 2Insulin/insulin-like growth factor-1Insulin-signaling pathwayEnergy homeostasisC. elegansIRS-2 pathwayLower organismsSubstrate 2Female reproductionRegulation of fertilityMetabolic signalsInsulin-like growth factor-1Reproductive statusFactor 1Infertile conditionsSevere dietary restrictionMammalsGrowth factor-1HomeostasisReproductionAnovulatory ovariesHypothalamic controlFemale infertilityPlasma concentrationsCatabolic state