2016
Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma
Metz H, Kargl J, Busch S, Kim K, Kurland B, Abberbock S, Randolph-Habecker J, Knoblaugh S, Kolls J, White M, Houghton A. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 8795-8800. PMID: 27439864, PMCID: PMC4978299, DOI: 10.1073/pnas.1601989113.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Janus kinase/signal transducerKinase/signal transducerTumor burdenActivator of transcriptionReceptor substrate-1IRS-1 deficiencyKRAS-mutant lung adenocarcinomaInsulin-like growth factor receptorAdenoviral Cre recombinaseIL-22 receptorMutant lung adenocarcinomaTumor-promoting inflammationAdaptor proteinSignificant survival disadvantageGrowth factor receptorSignal transducerSubstrate-1PI3KProinflammatory phenotypeLung cancerLung adenocarcinomaMutant subgroupTissue microarrayCre recombinase
2003
Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells*
Neid M, Datta K, Stephan S, Khanna I, Pal S, Shaw L, White M, Mukhopadhyay D. Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells*. Journal Of Biological Chemistry 2003, 279: 3941-3948. PMID: 14604996, DOI: 10.1074/jbc.m303975200.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBase SequenceCell Line, TumorDNA, NeoplasmFeedbackGene Expression Regulation, NeoplasticHumansInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsNeovascularization, PathologicPancreatic NeoplasmsPhosphoproteinsProtein Kinase CSignal TransductionSp1 Transcription FactorVascular Endothelial Growth Factor AConceptsVPF/VEGF expressionIRS proteinsIRS-2Negative feedback loopVEGF transcriptionPKC-zetaVascular Permeability Factor/Vascular Endothelial Growth Factor ExpressionPancreatic cancer cellsProtein kinase C zetaCancer cellsInsulin receptor substrate-1IGF-1RReceptor substrate-1Insulin receptor substrateIRS-2 proteinProtein kinase CMajor downstream moleculesInsulin-like growth factor receptorRenal cancer cellsVascular permeability factor/vascular endothelial growth factorIGF-1R signalingGrowth factorRas pathwayGrowth factor receptorC zeta
1997
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons*
Burfoot M, Rogers N, Watling D, Smith J, Pons S, Paonessaw G, Pellegrini S, White M, Kerr I. Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons*. Journal Of Biological Chemistry 1997, 272: 24183-24190. PMID: 9305869, DOI: 10.1074/jbc.272.39.24183.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Receptor substrate-1IRS-1IRS proteinsOncostatin MSubstrate-1Protein tyrosine kinasesKinase-dependent activationActivation of phosphatidylinositolJanus kinase (JAK) familyMutant cell linesHuman fibrosarcoma cell lineCell linesInsulin-like growth factor receptorHuman fibrosarcoma cellsKinase familyGrowth factor receptorFibrosarcoma cell lineIRS-2Cytokine receptorsType I interferonJAK1PhosphorylationAntiviral responseFibrosarcoma cells
1991
The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction
Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce J, Bottaro D, White M, Di Fiore P. The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction. Molecular And Cellular Biology 1991, 11: 3191-3202. DOI: 10.1128/mcb.11.6.3191-3202.1991.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignal transductionSpecificity of substrate recognitionErbB-2Specificity of signal transductionAmino-terminal halfDeletion of residuesMitogenic signaling pathwaysMitogenic signal transductionEGFR kinaseGrowth factor receptorSubstrate recognitionTyrosine kinase domainJuxtamembrane regionKinase domainStructural homologyKinase propertiesFactor receptorMutation analysisSignaling pathwayTyrosine kinaseChimeric moleculesKinaseTyrosineTransduction