2020
From population to neuron: exploring common mediators for metabolic problems and mental illnesses
Takayanagi Y, Ishizuka K, Laursen T, Yukitake H, Yang K, Cascella N, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White M, Eaton W, Mortensen P, Sakurai T, Sawa A. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Molecular Psychiatry 2020, 26: 3931-3942. PMID: 33173197, PMCID: PMC8514126, DOI: 10.1038/s41380-020-00939-5.Peer-Reviewed Original ResearchConceptsMajor mental illnessOlfactory neuronal cellsInsulin resistanceMental illnessBipolar disorderNeuronal cellsPathophysiological mediatorsHigh incidenceSZ patientsCommon mediatorIrs2 knockout miceSame large cohortIRS2 tyrosine phosphorylationDanish registriesBP patientsHealthy controlsHealthy subjectsLarge cohortEpidemiological dataEpidemiological studiesKnockout miceAnimal modelsPatientsMetabolic problemsDiabetes
2012
Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review
Behl M, Rao D, Aagaard K, Davidson T, Levin E, Slotkin T, Srinivasan S, Wallinga D, White M, Walker V, Thayer K, Holloway A. Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review. Environmental Health Perspectives 2012, 121: 170-180. PMID: 23232494, PMCID: PMC3569686, DOI: 10.1289/ehp.1205404.Peer-Reviewed Original ResearchConceptsMaternal smokingChildhood obesityMetabolic disordersRisk factorsChildhood overweight/obesityUnmeasured residual confoundingOverweight/obesityRisk of obesityCurrent epidemiological dataType 2 diabetesPotential risk factorsType 1 diabetesEarly life exposureEnvironmental chemicalsExperimental animal studiesPerinatal exposureMetabolic syndromeNicotine exposureMetabolic outcomesResidual confoundingEpidemiological dataCigarette smokeObesitySmokingAnimal studies