1998
The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action
White M, Yenush L. The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action. Current Topics In Microbiology And Immunology 1998, 228: 179-208. PMID: 9401207, DOI: 10.1007/978-3-642-80481-6_8.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylationSrc homology 2 domainTyrosine autophosphorylation sitesProtein-lipid interactionsAssembly of multicomponentSH2 proteinAutophosphorylation sitesPH domainSpecific membrane receptorsCytosolic substratesReceptor kinaseTyrosine autophosphorylationTransmembrane signalsCellular substratesCytokine receptorsActivity of receptorsMembrane receptorsEarly stepsPhosphorylationProteinKinaseGrowth factorCytokine actionReceptorsCascade
1996
The IRS-signalling system in insulin and cytokine action
White M, Marshall C. The IRS-signalling system in insulin and cytokine action. Philosophical Transactions Of The Royal Society B Biological Sciences 1996, 351: 181-189. PMID: 8650265, DOI: 10.1098/rstb.1996.0015.Peer-Reviewed Original ResearchConceptsIRS proteinsSrc homology 2 domainSH2 proteinAutophosphorylation sitesEndocytic pathwayTyrosine residuesIRS-2Cytokine receptorsRecent identificationStoichiometric constraintsMost receptorsIFN-alpha/betaAlpha/betaMultiple receptorsProteinNew insightsCytokine actionIL-13IL-4IGF-1IL-9ReceptorsIFN-gammaGrowth hormoneModular structure