2021
Irs2 deficiency alters hippocampus-associated behaviors during young adulthood
Tanokashira D, Wang W, Maruyama M, Kuroiwa C, White M, Taguchi A. Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. Biochemical And Biophysical Research Communications 2021, 559: 148-154. PMID: 33940386, PMCID: PMC8361845, DOI: 10.1016/j.bbrc.2021.04.101.Peer-Reviewed Original ResearchConceptsYoung adult male miceAdult male miceMale miceAlzheimer's diseaseType 2 diabetes mellitusInsulin-like growth factor-1Brain energy metabolismGrowth factor-1Young adult malesCore body temperatureDiabetes mellitusInsulin resistanceInsulin/insulin-like growth factor-1Risk factorsBehavioral alterationsCognitive impairmentGenetic backgroundPremature deathHippocampusMiceYoung adulthoodAberrant alterationsFactor 1Abnormal changesBody temperature
2014
IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity
White M. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity. Diabetes Obesity And Metabolism 2014, 16: 4-15. PMID: 25200290, DOI: 10.1111/dom.12347.Peer-Reviewed Original ResearchConceptsInsulin/IGF1Central nervous systemInsulin-like signalingLife spanOrganisms showsCellular functionsNutrient homeostasisInsulin resistanceGenetic manipulationSystemic insulin resistanceClinical Alzheimer's diseaseType 2 diabetesEnergy homeostasisNeurodegenerative diseasesMetabolismNeurodegenerationCompensatory hyperinsulinaemiaHomeostasisProgressive neurodegenerationSystemic metabolismIGF1Excess insulinNervous systemAlzheimer's diseaseClinical perspective
2011
IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation
Martín E, Sánchez-Perez A, Trejo J, Martin-Aldana J, Jaimez M, Pons S, Umanzor C, Menes L, White M, Burks D. IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation. Cerebral Cortex 2011, 22: 1717-1727. PMID: 21955917, PMCID: PMC3388895, DOI: 10.1093/cercor/bhr216.Peer-Reviewed Original ResearchConceptsLong-term potentiationInduction of LTPInsulin receptor substrate 2Activation of FynPotential new componentSynaptic transmissionSynaptic plasticityWild-type controlsSubstrate 2Alzheimer's diseasePostsynaptic N-methyl-D-aspartate receptorsIRS2 expressionN-methyl-D-aspartate receptorsImpairs long-term potentiationInsulin-like growth factor IMechanistic linkNMDA receptor-dependent long-term potentiationType 2 diabeticsBasal synaptic transmissionExpression of NR2AGroups of miceGrowth factor IPaired-pulse facilitationNeurodegenerative disordersTetanus stimulation