2010
Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models
Cheng Z, White M. Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models. Antioxidants & Redox Signaling 2010, 14: 649-661. PMID: 20615072, PMCID: PMC3025764, DOI: 10.1089/ars.2010.3370.Peer-Reviewed Original ResearchConceptsForkhead box O (FOXO) transcription factorsInsulin receptor substratePhosphoenolpyruvate carboxykinaseActivation of FOXO1Β-cellsRegulation of metabolismAkt signal cascadeRole of FoxO1Transcriptional regulationForkhead box O1Β-cell proliferationStress resistanceTranscription factorsDuodenal homeobox 1Mitochondrial metabolismPancreatic β-cellsReceptor substrateSignal cascadeΒ-cell failureLipid switchesCarboxypeptidase E.Mouse modelHomeobox 1Metabolic diseasesInhibition of FOXO1
1999
Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling
COUSIN S, HülGL S, MYERS M, WHITE M, REIFEL-MILLER A, RHODES C. Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochemical Journal 1999, 344: 649-658. DOI: 10.1042/bj3440649.Peer-Reviewed Original ResearchINS-1 cell proliferationSignal transduction pathwaysΒ-cell proliferationSignal transductionCell proliferationKinase 2Sevenless-1 proteinMitogenic signal transduction pathwaysJAK2/STAT5 pathwayΒ-cellsMitogen-activated protein kinaseRat growth hormoneJAK2/STAT5Rat β-cell linePancreatic β-cell proliferationΒ-cell lineMitogenic signalingS6 kinaseProtein kinaseProtein associationTranscription 5Pancreatic β-cellsReceptor substrateKinase activationDifferent mitogenic