2023
Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease
O'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 39: 103457. PMID: 37422964, PMCID: PMC10338149, DOI: 10.1016/j.nicl.2023.103457.Peer-Reviewed Original ResearchConceptsCognitive domainsCognitive performanceSubjects' scoresCortical regionsNeuropsychological batteryEarly Alzheimer's diseaseAD groupBilateral regionsNormal participantsNegative loadingsCognitive impairmentCN participantsAlzheimer's diseaseParticipantsStructural correlatesStrong contributionParticipant characteristicsScoresPositive loadingsData-driven approachTotal variancePrincipal component analysisSpecific spatial patterns
2019
Atlas-Based Multiorgan Segmentation for Dynamic Abdominal PET
Ren S, Laub P, Lu Y, Naganawa M, Carson R. Atlas-Based Multiorgan Segmentation for Dynamic Abdominal PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2019, 4: 50-62. DOI: 10.1109/trpms.2019.2926889.Peer-Reviewed Original ResearchMultiorgan segmentationSegmentation methodDynamic image seriesDynamic imagesFrames of dataHyperparameter optimizationAutomatic frameworkSegmentation frameworkDynamic PET imagesSegmentation resultsGraph cutsFinal segmentationHyperparameter combinationsTemporal informationAtlas informationPET imagesTissue time-activity curvesManual segmentationSegmentationImage seriesGaussian distributionPrincipal component analysisBetter performanceImagesDifferent activity distributions