2000
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
Schechner J, Nath A, Zheng L, Kluger M, Hughes C, Sierra-Honigmann M, Lorber M, Tellides G, Kashgarian M, Bothwell A, Pober J. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9191-9196. PMID: 10890921, PMCID: PMC16844, DOI: 10.1073/pnas.150242297.Peer-Reviewed Original Research
1994
Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia
Van Why S, Mann A, Ardito T, Siegel N, Kashgarian M. Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia. American Journal Of Physiology 1994, 267: f75-f85. PMID: 8048568, DOI: 10.1152/ajprenal.1994.267.1.f75.Peer-Reviewed Original Research
1991
Redistribution of cellular energy following renal ischemia
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Redistribution of cellular energy following renal ischemia. Pediatric Nephrology 1991, 5: 591-596. PMID: 1911145, DOI: 10.1007/bf00856647.Peer-Reviewed Original Research
1990
Morphological and physiological responses to aldosterone: time course and sodium dependence
Wade J, Stanton B, Field M, Kashgarian M, Giebisch G. Morphological and physiological responses to aldosterone: time course and sodium dependence. American Journal Of Physiology 1990, 259: f88-f94. PMID: 2375395, DOI: 10.1152/ajprenal.1990.259.1.f88.Peer-Reviewed Original ResearchConceptsOsmotic minipumpsMale Sprague-Dawley ratsPrincipal cellsElevated aldosterone levelsSprague-Dawley ratsImplanted osmotic minipumpsTime courseBasolateral membraneAldosterone levelsIntravenous infusionAldosterone treatmentPhysiological elevationReplacement infusionsAldosteroneAcute exposureChronic exposureDetectable proliferationFurther elevationDays of exposureSodium dependenceBasolateral membrane areaMinipumpsInfusionSecretionExposureUltrastructural characteristics of rat peritoneal mast cells undergoing differential release of serotonin without histamine and without degranulation
Kops S, Theoharides T, Cronin C, Kashgarian M, Askenase P. Ultrastructural characteristics of rat peritoneal mast cells undergoing differential release of serotonin without histamine and without degranulation. Cell And Tissue Research 1990, 262: 415-424. PMID: 1706643, DOI: 10.1007/bf00305238.Peer-Reviewed Original Research
1989
Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitorFormation of extracellular matrix by cultured rat mesangial cells.
Ishimura E, Sterzel R, Budde K, Kashgarian M. Formation of extracellular matrix by cultured rat mesangial cells. American Journal Of Pathology 1989, 134: 843-55. PMID: 2650558, PMCID: PMC1879799.Peer-Reviewed Original ResearchUltrastructure of Amphiuma distal nephron: evidence for cellular heterogeneity
Biemesderfer D, Stanton B, Wade J, Kashgarian M, Giebisch G. Ultrastructure of Amphiuma distal nephron: evidence for cellular heterogeneity. American Journal Of Physiology 1989, 256: c849-c857. PMID: 2705516, DOI: 10.1152/ajpcell.1989.256.4.c849.Peer-Reviewed Original ResearchAnkyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells.
Morrow J, Cianci C, Ardito T, Mann A, Kashgarian M. Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells. Journal Of Cell Biology 1989, 108: 455-465. PMID: 2537316, PMCID: PMC2115445, DOI: 10.1083/jcb.108.2.455.Peer-Reviewed Original ResearchConceptsMadin-Darby canine kidney cellsCanine kidney cellsK-ATPaseAlpha subunitMolecular mechanismsMDCK cellsMinor membrane proteinsDistribution of fodrinErythrocyte ankyrinConfluent MDCK cellsBinding of ankyrinKidney cellsHuman erythrocyte ankyrinRenal epithelial cellsCytoplasmic domainNonerythroid cellsMembrane proteinsCortical cytoskeletonBasolateral domainMembrane skeletonPolarized distributionAnkyrinBasolateral marginsCell developmentErythrocyte band 3
1988
Morphological heterogeneity of the rabbit collecting duct
Ridderstrale Y, Kashgarian M, Koeppen B, Giebisch G, Stetson D, Ardito T, Stanton B. Morphological heterogeneity of the rabbit collecting duct. Kidney International 1988, 34: 655-670. PMID: 2462075, DOI: 10.1038/ki.1988.230.Peer-Reviewed Original Research
1986
Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture.
Sterzel R, Lovett D, Foellmer H, Perfetto M, Biemesderfer D, Kashgarian M. Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. American Journal Of Pathology 1986, 125: 130-40. PMID: 3535527, PMCID: PMC1888434.Peer-Reviewed Original ResearchConceptsMesangial cellsNecrotic cell debrisCollagen type IMesangial matrix productionCultured mesangial cellsGlomerular mesangial cellsIsolated rat glomeruliType ISpecific rabbit polyclonal antibodiesNodular fociFetal calf serumDiseased glomeruliMC proliferationRabbit polyclonal antibodyStellate cellsNormal glomeruliMatrix proteinsInterstitial collagen types ICell debrisImmunocytochemical studyNodular accumulationMetabolic stimuliIntracellular fibrilsRat glomeruliGlomeruliNo aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats.
Stein H, Sterzel R, Hunt J, Pabst R, Kashgarian M. No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats. American Journal Of Pathology 1986, 122: 520-30. PMID: 3513602, PMCID: PMC1888211.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAntibodies, Anti-IdiotypicAntibody FormationAutoradiographyBlood PressureFluorescent Antibody TechniqueGlomerulonephritisHistocytochemistryHypertensionImmune System DiseasesImmunoglobulin GKidneyMaleMicroscopy, ElectronRabbitsRatsRats, Inbred SHRRats, Inbred WKYThymidineConceptsWistar-Kyoto controlsBlood pressureGBM nephritisRenal injurySystemic hypertensionHypertensive ratsNormotensive Wistar-Kyoto (WKY) controlsAntiglomerular basement membrane nephritisUrinary albumin excretionSystolic blood pressureIgG antibody productionHumoral antibody responseNonspecific esteraseLight microscopyAlbumin excretionAutoregulatory capacityControl SHRMild hypertensionMorphologic injuryCreatinine clearanceGlomerular alterationsSerum creatinineNSE stainingHumoral responseAntibody responseUbiquinone-8 Stimulates Phagocytosis in Macrophages by Modulation of the Kinetics of the Fc Receptor
Block L, Georgopoulos A, Biemesderfer D, Herzog C, Kashgarian M, Sitaramam V. Ubiquinone-8 Stimulates Phagocytosis in Macrophages by Modulation of the Kinetics of the Fc Receptor. The Journal Of Infectious Diseases 1986, 153: 209-215. PMID: 3944478, DOI: 10.1093/infdis/153.2.209.Peer-Reviewed Original ResearchProgressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis
Foellmer H, Sterzel R, Kashgarian M. Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis. American Journal Of Kidney Diseases 1986, 7: 5-11. PMID: 3510536, DOI: 10.1016/s0272-6386(86)80050-6.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateAntiglomerular basement membrane glomerulonephritisProgressive glomerular sclerosisGlomerular sclerosisPara-aminohippuric acidGlomerular hypercellularityFiltration fractionWistar ratsInitial inflammatory changesNormal renal clearanceIntrinsic glomerular cellsChronic glomerulosclerosisRenal insufficiencyInflammatory changesAcute phaseChronic phaseSignificant proteinuriaFiltration rateLeukocytic infiltrationCrescent formationFunctional abnormalitiesSclerotic processRenal clearanceGlomerular cellsGlomerulonephritis
1985
Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segments
Kashgarian M, Biemesderfer D, Caplan M, Forbush B. Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segments. Kidney International 1985, 28: 899-913. PMID: 3003443, DOI: 10.1038/ki.1985.216.Peer-Reviewed Original ResearchConceptsMonoclonal antibodiesNephron segmentsEvidence of labellingRenal tubular epithelial cellsTubular epithelial cellsK-ATPaseThick ascending limbOnly principal cellsDifferent nephron segmentsDog antigensBasal-lateral membranesSignificant antibodiesAscending limbMesangial regionHenle's loopOccasional cellsRenal medullaOuter renal medullaAbundant antibodyAntibodiesApical labelingTubule segmentsPrincipal cellsEpithelial cellsImmunocytochemical localization
1984
Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium
Stanton B, Biemesderfer D, Stetson D, Kashgarian M, Giebisch G. Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium. American Journal Of Physiology 1984, 247: c204-c216. PMID: 6476108, DOI: 10.1152/ajpcell.1984.247.3.c204.Peer-Reviewed Original ResearchConceptsEarly distal tubuleDistal tubulesDistal nephronPotassium adaptationRenal distal nephronLarge cell typeLate distal tubuleCortical collecting tubuleSmooth muscle cellsLate distalAfferent arteriolesEffects of exposureJuxtaglomerular apparatusMammalian cortical collecting tubuleCollecting tubuleEarly distalHenle's loopBasolateral membrane surface densityMuscle cellsPrincipal cellsCellular mechanismsNephronStereological techniquesTubulesUseful preparation
1983
Disposal of ferritin in the glomerular mesangium of rats
Sterzel R, Perfetto M, Biemesderfer D, Kashgarian M. Disposal of ferritin in the glomerular mesangium of rats. Kidney International 1983, 23: 480-488. PMID: 6188874, DOI: 10.1038/ki.1983.45.Peer-Reviewed Original ResearchConceptsGlomerular mesangiumDay 3DE ratsVascular poleIa-negative cellsMacula densa cellsIa-positive cellsGlomerular stainingMacula densaMesangial patternIntravenous injectionRenal tissueFerritin injectionIa antigensGlomerular tuftBearing cellsMesangial matrixMesangial cellsLacis areaMesangiumRatsCryostat sectionsInterstitial areaStudy periodFerritin
1982
The mesangium and glomerulonephritis
Sterzel R, Lovett D, Stein H, Kashgarian M. The mesangium and glomerulonephritis. Journal Of Molecular Medicine 1982, 60: 1077-1094. PMID: 7144055, DOI: 10.1007/bf01715838.Peer-Reviewed Original ResearchConceptsGlomerular diseaseImmune competent cellsProgressive glomerular sclerosisExperimental glomerular diseaseMesangial cell proliferationMesangial spacePeripheral capillary wallsCertain glomerular diseasesLocal hemodynamic factorsIntrinsic mesangial cellsGlomerular basement membraneMesangial dysfunctionGlomerular sclerosisInflammatory cellsGlomerular hypertensionHistopathologic studyMarked proteinuriaGlomerular disordersSubendothelial depositsPericapillary tissueTherapeutic approachesImmune complexesFunctional damageMesangial abnormalitiesCapillary pericytesMesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.
Sterzel R, Ehrich J, Lucia H, Thomson D, Kashgarian M. Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats. Laboratory Investigation 1982, 46: 209-14. PMID: 7038293.Peer-Reviewed Original ResearchConceptsGlomerular immune depositsImmune depositsElectron-dense depositsDay 10Day 20Young Sprague-Dawley ratsRenal functional damageUrinary protein excretionInfiltration of monocytesGlomerular cell countSprague-Dawley ratsEsterase-positive monocytesGlomerular basement membraneAcute malariaProtein excretionGlomerular injuryMesangial distributionSerum urea valuesDay 100Granular depositionImmune complexesFunctional damageNormal rangeMesangial matrixCell count"Clear-cell" change within duct and lobular epithelium of the human breast.
Barwick K, Kashgarian M, Rosen P. "Clear-cell" change within duct and lobular epithelium of the human breast. Anatomic Pathology 1982, 17 (Pt 1): 319-28. PMID: 7122130.Peer-Reviewed Original Research