2010
Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI
Gotoh N, Yan Q, Du Z, Biemesderfer D, Kashgarian M, Mooseker MS, Wang T. Altered renal proximal tubular endocytosis and histology in mice lacking myosin‐VI. Cytoskeleton 2010, 67: 178-192. PMID: 20175219, PMCID: PMC3468331, DOI: 10.1002/cm.20435.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsApoptosis Regulatory ProteinsCell TransdifferentiationEndocytosisHorseradish PeroxidaseKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2MiceMice, Neurologic MutantsMicrofilament ProteinsMicrovilliMyosin Heavy ChainsVesicular Transport ProteinsConceptsProximal tubule cellsAlbumin excretionSv miceTubule cellsProximal tubule brush borderGlomerular flow rateProximal tubular dilationUrinary albumin excretionElevated blood pressureReduced body weightProximal tubular endocytosisRenal proximal tubule brush borderTubule brush borderProximal tubular uptakeBlood acid-base parametersMouse kidney proximal tubulesKidney proximal tubulesBlood pressureUrine volumeUrinary excretionAcid-base parametersRenal homogenatesTubular dilationPlasma concentrationsRenal clearance
2001
K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells
Eickelberg O, Geibel J, Seebach F, Giebisch G, Kashgarian M. K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells. American Journal Of Physiology. Renal Physiology 2001, 281: f280-f287. PMID: 11457719, DOI: 10.1152/ajprenal.2001.281.2.f280.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium Channel BlockersCell LineDiltiazemEgtazic AcidEnzyme InhibitorsEpithelial CellsGallic AcidGenes, ReporterHeat-Shock ProteinsHSP72 Heat-Shock ProteinsImmunoblottingKidney Tubules, ProximalMicroscopy, ConfocalPotassiumPromoter Regions, GeneticRecombinant Fusion ProteinsSodiumSwineThapsigarginUrotheliumConceptsHSP 72 expressionPromoter activityHSP 72Protein expressionProtective cellular responseLuciferase reporter geneHSP-25Heat shock protein expressionRenal epithelial cellsTranscriptional inductionShock protein expressionIonic stressReporter geneHSP-90 levelsHSC 73Cellular responsesChannel blocker diltiazemIntracellular lumenWestern blot analysisChelator EGTA-AMPathophysiological stimuliBlot analysisConfocal microscopyProtein levelsExtracellular space
1998
Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia
Aufricht C, Ardito T, Thulin G, Kashgarian M, Siegel N, Van Why S. Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia. American Journal Of Physiology 1998, 274: f215-f222. PMID: 9458842, DOI: 10.1152/ajprenal.1998.274.1.f215.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAorta, AbdominalCytoskeletonHeat-Shock ProteinsIschemiaKidneyKidney Tubules, ProximalMaleRatsRats, Sprague-DawleyRenal ArteryConceptsHSP-25Renal ischemiaHeat shock protein 25Ischemic renal injuryH reflowRat renal cortexControl proximal tubulesRenal injuryPostischemic recoveryRenal cortexIschemiaProximal tubulesIntracytoplasmic accumulationPeak levelsHeat shock proteinsProtein 25Actin stainingInsoluble cytoskeletal fractionPunctate accumulationsCytoskeletal disruptionSmall heat shock proteinsRegulatory roleInductionIntracellular distributionCytoskeletal fraction
1994
Immature Renal Tubules Are Resistant to Prolonged Anoxia
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Immature Renal Tubules Are Resistant to Prolonged Anoxia. Pediatric Research 1994, 35: 152-156. PMID: 8165048, DOI: 10.1203/00006450-199402000-00005.Peer-Reviewed Original ResearchAdenosine TriphosphateAnimalsDNAHypoxiaIn Vitro TechniquesKidney Tubules, ProximalL-Lactate DehydrogenaseRats
1989
Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys. American Journal Of Physiology 1989, 257: f383-f389. PMID: 2551186, DOI: 10.1152/ajprenal.1989.257.3.f383.Peer-Reviewed Original ResearchConceptsProximal tubule suspensionsIschemic injuryTubule suspensionsRenal artery ischemiaVivo ischemic injurySprague-Dawley ratsMin of reflowOxygen consumptionPresence of ouabainBasal O2 consumptionArtery ischemiaIschemic kidneyHistopathological appearanceMetabolic alterationsProximal tubulesControl levelsProtein 1
1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENa
1983
Accelerated cellular recovery after an ischemic renal injury.
Gaudio K, Ardito T, Reilly H, Kashgarian M, Siegel N. Accelerated cellular recovery after an ischemic renal injury. American Journal Of Pathology 1983, 112: 338-46. PMID: 6604459, PMCID: PMC1916386.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsHorseradish PeroxidaseInulinIschemiaKidneyKidney Tubules, ProximalMaleNecrosisPressureRatsRats, Inbred StrainsConceptsProximal tubular pressureCellular morphologic featuresRenal ischemiaATP-MgCl2Back leakTubular integrityMorphologic featuresCellular damageIschemic cellular damageProgressive ischemic injurySevere ischemic damageIschemic renal injurySaline-treated ratsGroups of ratsEarly regenerative changesRenal injuryIschemic damageIschemic injuryIschemic alterationsNormal salineRegenerative changesSaline ratsEnhances recoverySalutary effectsHistomorphometric analysis
1982
Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2
Gaudio K, Taylor M, Chaudry I, Kashgarian M, Siegel N. Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2. Kidney International 1982, 22: 13-20. PMID: 7120752, DOI: 10.1038/ki.1982.126.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsInulinIschemiaKidney Tubules, ProximalMagnesiumMagnesium ChlorideMaleNephronsPressureRatsRats, Inbred StrainsSodium ChlorideTime FactorsConceptsClearance of inulinSingle nephron functionATP-MgCl2Proximal tubular pressureNephron functionTubular pressureBeneficial effectsRenal artery ischemiaSaline-treated animalsSaline-treated ratsCourse of recoveryGroups of animalsPostischemic administrationArtery ischemiaPattern of recoveryCIN 1Postischemic infusionInitial insultInulin clearanceInitial improvementControl animalsMost epithelial cellsEnhanced recoveryWhole kidneyTubular fluid
1980
Renal perfusion and intratubular pressure during ureteral occlusion in the rat
Gaudio K, Siegel N, Hayslett J, Kashgarian M. Renal perfusion and intratubular pressure during ureteral occlusion in the rat. American Journal Of Physiology 1980, 238: f205-f209. PMID: 7369362, DOI: 10.1152/ajprenal.1980.238.3.f205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBody WeightHydrostatic PressureKidneyKidney Tubules, ProximalMalePressureRatsRegional Blood FlowTime FactorsUreteral ObstructionConceptsTotal renal blood flowBilateral ureteral occlusionBody wt-1Tubular hydrostatic pressureUreteral occlusionKidney 1WT-1Renal blood flowRenal hemodynamicsRenal perfusionIntratubular pressureBlood flowControl animalsSustained increasePeak riseOcclusionMmHgIndomethacinSubsequent time intervalsRatsPatterns of changeAlterationsAnimalsPrimary roleSubsequent time periods
1979
A micropuncture study of the renal handling of lithium
Hayslett J, Kashgarian M. A micropuncture study of the renal handling of lithium. Pflügers Archiv - European Journal Of Physiology 1979, 380: 159-163. PMID: 573443, DOI: 10.1007/bf00582152.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Membrane PermeabilityKidney TubulesKidney Tubules, CollectingKidney Tubules, DistalKidney Tubules, ProximalLithiumMaleRatsConceptsMicropuncture studiesProximal tubulesLoop of HenleTubular fluid samplesNephron sitesNet transepithelial movementRenal handlingLithium reabsorptionDistal tubulesClearance studiesTubular fluidProximal convolutionExperimental animalsDistal portionFluid samplesTubulesTransepithelial movementHenleNephron
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9RatsMicropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney
Hecht B, Kashgarian M, Forrest J, Hayslett J. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney. Pflügers Archiv - European Journal Of Physiology 1978, 377: 69-74. PMID: 569282, DOI: 10.1007/bf00584376.Peer-Reviewed Original ResearchConceptsFractional reabsorptionDistal tubule functionProximal fractional reabsorptionPlasma lithium concentrationReabsorption of bicarbonateMultiple nephron segmentsEnd-proximal tubuleEffects of lithiumLithium treatmentPotassium secretionAntidiuretic hormoneDistal tubulesMicropuncture studiesTubule functionProximal tubulesDistal convolutionExperimental animalsNephron segmentsReabsorptionDistal portionTubulesPrevious studiesRatsSodiumHormone
1974
Na-K-ATPase-mediated seasonal variation of sodium transport in Necturus kidney
Spector D, Hayslett J, Kashgarian M. Na-K-ATPase-mediated seasonal variation of sodium transport in Necturus kidney. American Journal Of Physiology 1974, 227: 873-877. PMID: 4279558, DOI: 10.1152/ajplegacy.1974.227.4.873.Peer-Reviewed Original ResearchEffect of luminal permeability on net transport across the amphibian proximal tubule
Stroup R, Weinman E, Hayslett J, Kashgarian M. Effect of luminal permeability on net transport across the amphibian proximal tubule. American Journal Of Physiology 1974, 226: 1110-1116. PMID: 4824863, DOI: 10.1152/ajplegacy.1974.226.5.1110.Peer-Reviewed Original Research
1973
Increased tubular reabsorption of sodium in compensatory renal growth
Weinman E, Renquist K, Stroup R, Kashgarian M, Hayslett J. Increased tubular reabsorption of sodium in compensatory renal growth. American Journal Of Physiology 1973, 224: 565-571. PMID: 4691269, DOI: 10.1152/ajplegacy.1973.224.3.565.Peer-Reviewed Original Research
1972
Examination of the Gertz technique as applied to the proximal tubule of the rat kidney.
Weinman E, Hardy R, Kashgarian M, Hayslett J. Examination of the Gertz technique as applied to the proximal tubule of the rat kidney. The Yale Journal Of Biology And Medicine 1972, 45: 289-98. PMID: 4638651, PMCID: PMC2591948.Peer-Reviewed Original Research