1994
Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.
Van Why S, Mann A, Thulin G, Zhu X, Kashgarian M, Siegel N. Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat. Journal Of Clinical Investigation 1994, 94: 1518-1523. PMID: 7929828, PMCID: PMC295298, DOI: 10.1172/jci117492.Peer-Reviewed Original ResearchConceptsRenal cortexHsp-70 mRNA inductionCortical ATP levelsRenal ischemia resultsPartial aortic occlusionActivation of HSFATP levelsCellular ATPHSF activationHSP-70 mRNAReduction of ATPAortic occlusionPreocclusion levelsProfound fallTotal occlusionIschemia resultsPreocclusion valuesHeat shock transcription factorLow-level expressionMetabolic consequencesVivo 31P NMR spectroscopyControl valuesHSP-70Vigorous responseRenal ATP
1986
Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism
Jaeger P, Jones W, Hayslett J, Kashgarian M, Segre G. Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism. Advances In Experimental Medicine And Biology 1986, 208: 379-382. PMID: 3565154, DOI: 10.1007/978-1-4684-5206-8_47.Peer-Reviewed Original Research
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnimalsBlood PressureGlomerular Filtration RateKidneyKidney CortexMaleRatsRegional Blood FlowConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increaseRenal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy
1976
Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure.
Kashgarian M, Siegel N, Ries A, DiMeola H, Hayslett J. Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure. Kidney International Supplement 1976, 6: s160-8. PMID: 1068320.Peer-Reviewed Original Research
1974
Intrarenal hemodynamics in postobstructive diuresis.
Feldman R, Siegel N, Kashgarian M, Hayslett J, Lytton B. Intrarenal hemodynamics in postobstructive diuresis. Journal Of Urology 1974, 12: 172-5. PMID: 4443183.Peer-Reviewed Original Research