2008
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Geller DS, Zhang J, Wisgerhof MV, Shackleton C, Kashgarian M, Lifton RP. A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 3117-3123. PMID: 18505761, PMCID: PMC2515083, DOI: 10.1210/jc.2008-0594.Peer-Reviewed Original ResearchConceptsGlucocorticoid-remediable aldosteronismAdrenal fasciculataAdministration of dexamethasoneAdrenal steroid productionAdrenal steroid biosynthesisNew familial formAge 7 yrSecondary hypertensionBilateral adrenalectomyMost patientsPrimary aldosteronismAdrenal weightClinical syndromeAdrenal glandCortisol secretionLeading causeAldosteronismHypertensionMedical treatmentAldosterone synthaseSteroid productionAutosomal dominant formCellular hypertrophyCortical compartmentFamilial forms
1992
Can Experienced Clinicians Predict the Outcome of Lupus Nephritis?
Esdaile J, Mackenzie T, Barré P, Danoff D, Kirk Osterland C, Somerville P, Quintal H, Kashgarian M, Suissa S. Can Experienced Clinicians Predict the Outcome of Lupus Nephritis? Lupus 1992, 1: 205-214. PMID: 1301984, DOI: 10.1177/096120339200100403.Peer-Reviewed Original Research
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patients
1989
The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature.
Esdaile J, Levinton C, Federgreen W, Hayslett J, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM 1989, 72: 779-833. PMID: 2694209.Peer-Reviewed Original ResearchConceptsPresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseClinical modelRenal insufficiencyRenal failurePrognostic markerRelevant long-term outcomesRenal systemic lupus erythematosusImmunologic disease activityNon-renal SLESystemic lupus erythematosusImportant prognostic markerChronicity indexRenal outcomesRenal severityDisease activityNew predictive informationSerum creatinineConsecutive patientsLupus erythematosusPrognostic factorsRenal biopsyComorbid conditions
1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1980
The importance of nonrenal involvement in hemolytic-uremic syndrome.
Upadhyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel N. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics 1980, 65: 115-20. PMID: 7355005, DOI: 10.1542/peds.65.1.115.Peer-Reviewed Original Research
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroidsClinical Aspects of Bilateral Renal Dysplasia in Children
Gur A, Siegel N, Davis C, Kashgarian M, Hayslett J. Clinical Aspects of Bilateral Renal Dysplasia in Children. Nephron 1975, 15: 50-61. PMID: 236522, DOI: 10.1159/000180492.Peer-Reviewed Original ResearchConceptsBilateral renal dysplasiaRenal dysplasiaClinical featuresClinical aspectsProgressive renal deteriorationLong-term prognosisRenal deteriorationBilateral involvementClinical courseUrinary concentrationsLaurence-MoonBiedl syndromePathogenic mechanismsDysplasiaPaucity of informationPatientsChildrenLarge proportionPrognosisSyndromeImpairmentGlomerulonephropathy.
Hayslett J, Siegel N, Kashgarian M. Glomerulonephropathy. Advances In Internal Medicine 1975, 20: 215-48. PMID: 1090119.Peer-Reviewed Original ResearchAdolescentAdultAmyloidosisBasement MembraneBlood Coagulation DisordersChildChild, PreschoolDiabetic NephropathiesFemaleGlomerulonephritisGranulomatosis with PolyangiitisHematuriaHumansImmunoglobulin GImmunoglobulin MKidney DiseasesKidney GlomerulusLupus Erythematosus, SystemicMaleMiddle AgedNephrosis, LipoidProteinuriaStreptococcal InfectionsUremia
1974
Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1973
CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE
HAYSLETT J, KASHGARIAN M, BENSCH K, SPARGO B, FREEDMAN L, EPSTEIN F. CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE. Medicine 1973, 52: 93-120. PMID: 4695844, DOI: 10.1097/00005792-197303000-00001.Peer-Reviewed Original ResearchAcute DiseaseAdolescentAdultAgedAutopsyAzathioprineBiopsyChildChild, PreschoolChronic DiseaseFemaleFollow-Up StudiesGlomerulonephritisHumansKidney DiseasesKidney Function TestsMaleMicroscopy, ElectronMiddle AgedNephrosis, LipoidNephrotic SyndromePrednisonePrognosisProteinuriaRemission, SpontaneousSerum AlbuminUrine
1969
Progression of Lipoid Nephrosis to Renal Insufficiency
Hayslett J, Krassner L, Bensch K, Kashgarian M, Epstein F. Progression of Lipoid Nephrosis to Renal Insufficiency. New England Journal Of Medicine 1969, 281: 181-187. PMID: 5790494, DOI: 10.1056/nejm196907242810402.Peer-Reviewed Original Research