2011
A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice
Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice. The Journal Of Immunology 2011, 186: 527-538. PMID: 21106847, PMCID: PMC3124407, DOI: 10.4049/jimmunol.1001767.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell Migration InhibitionFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGlomerulonephritisHumansIntramolecular OxidoreductasesIsoxazolesLupus Erythematosus, SystemicMacrophage Migration-Inhibitory FactorsMiceMice, Inbred MRL lprMice, Inbred NZBMice, KnockoutMolecular Sequence DataRandom AllocationReceptors, ImmunologicConceptsMacrophage migration inhibitory factorMRL/lpr miceNZB/NZW F1Systemic lupus erythematosusMigration inhibitory factorLupus erythematosusLpr miceDihydro-5-isoxazole acetic acid methyl esterHigh-expression MIF allelesInhibitory factorExcessive proinflammatory responsesRetention of monocytesEnd-organ injuryEnd-organ damageProinflammatory cytokine productionDifferent autoimmune diseasesB cell activationMIF antagonismMIF antagonistAutoantibody productionChemokine expressionProinflammatory cytokinesAutoimmune diseasesCytokine productionMIF alleles
2010
Dendritic Cells in Lupus Are Not Required for Activation of T and B Cells but Promote Their Expansion, Resulting in Tissue Damage
Teichmann LL, Ols ML, Kashgarian M, Reizis B, Kaplan DH, Shlomchik MJ. Dendritic Cells in Lupus Are Not Required for Activation of T and B Cells but Promote Their Expansion, Resulting in Tissue Damage. Immunity 2010, 33: 967-978. PMID: 21167752, PMCID: PMC3010763, DOI: 10.1016/j.immuni.2010.11.025.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesBlood Component RemovalB-LymphocytesCell DifferentiationCell MovementDendritic CellsDisease Models, AnimalHumansImmunoglobulin Class SwitchingInterferon-gammaLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred MRL lprT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryConceptsDendritic cellsAdaptive immune responsesMurine lupusImmune responseAbsence of DCsEffects of DCsSystemic lupus erythematosusSerum immunoglobulin concentrationsPotential therapeutic targetLupus erythematosusInterstitial infiltratesAutoimmune disordersHumoral responseAutoantibody concentrationsPlasmablast numbersImmunoglobulin concentrationsTherapeutic targetB cellsTissue damageLupusCell numberCellsInitial activationComplex roleActivation