2021
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data
Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisInterstitial nephritisUrine biomarkersBiopsy-proven acute interstitial nephritisElectronic health record dataExternal validation cohortTypical clinical featuresBlood urea nitrogenTumor necrosis factorCharacteristic curve analysisHealth record dataExternal validationElectronic health recordsAIN diagnosisModest AUCsSerum creatinineCreatinine ratioKidney biopsyClinical featuresValidation cohortNecrosis factorUnrecognized casesInterleukin-9PatientsUrea nitrogen
2019
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease
1998
Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Perazella M, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clinical Nephrology 1998, 50: 194-6. PMID: 9776425.Peer-Reviewed Original ResearchConceptsRenal biopsy findingsRenal insufficiencyBiopsy findingsMild renal insufficiencyAcute renal failureIndinavir crystalsIndinavir therapyRenal failureAntiretroviral agentsUrinary obstructionAIDS patientsCellular castsPatientsPyuriaInsufficiencyRecent reportsSmall percentDiscontinuationNephropathyMedicationsSecond caseDiuresisNephrolithiasisIndinavirObstruction
1996
The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis
Kashgarian M. The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis. Renal Failure 1996, 18: 765-773. PMID: 8903091, DOI: 10.3109/08860229609047705.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusLong-term outcomesCourse of diseaseWorld Health OrganizationMorphologic modalitiesKidney biopsyRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationImmune responseIndividual patientsSame patientBiopsy interpretationNephritisPatientsBiopsySemiquantitative assessmentDifferent patientsHealth Organization
1994
The benefit of early treatment with immunosuppressive agents in lupus nephritis.
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The benefit of early treatment with immunosuppressive agents in lupus nephritis. The Journal Of Rheumatology 1994, 21: 2046-51. PMID: 7869308.Peer-Reviewed Original ResearchConceptsHour urinary protein excretionUrinary protein excretionLead-time biasRenal biopsyLupus nephritisRenal insufficiencyRenal involvementSerum creatinineProtein excretionImmunosuppressive agentsEarly treatmentHigh-dose prednisoneLupus renal involvementSubsequent renal insufficiencyTime biasFirst renal biopsySelection biasDose prednisoneTubulointerstitial indexRenal diseaseLongterm prognosisImmunosuppressive drugsEffect of durationBiopsySignificant associationThe Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictors
1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern
1992
Can Experienced Clinicians Predict the Outcome of Lupus Nephritis?
Esdaile J, Mackenzie T, Barré P, Danoff D, Kirk Osterland C, Somerville P, Quintal H, Kashgarian M, Suissa S. Can Experienced Clinicians Predict the Outcome of Lupus Nephritis? Lupus 1992, 1: 205-214. PMID: 1301984, DOI: 10.1177/096120339200100403.Peer-Reviewed Original ResearchClinical significance of renal biopsy in subacute lupus erythematosus
Kashgarian M. Clinical significance of renal biopsy in subacute lupus erythematosus. Transfusion And Apheresis Science 1992, 13: 135-144. PMID: 10148125, DOI: 10.1016/0955-3886(92)90164-c.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusSubacute lupus erythematosusCourse of illnessLong-term courseWorld Health OrganizationLupus nephropathyMorphologic modalitiesRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationClinical significanceImmune responseIndividual patientsSame patientBiopsy interpretationPatientsNephritisSemiquantitative assessmentTerm course
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patients
1989
The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature.
Esdaile J, Levinton C, Federgreen W, Hayslett J, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM 1989, 72: 779-833. PMID: 2694209.Peer-Reviewed Original ResearchConceptsPresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseClinical modelRenal insufficiencyRenal failurePrognostic markerRelevant long-term outcomesRenal systemic lupus erythematosusImmunologic disease activityNon-renal SLESystemic lupus erythematosusImportant prognostic markerChronicity indexRenal outcomesRenal severityDisease activityNew predictive informationSerum creatinineConsecutive patientsLupus erythematosusPrognostic factorsRenal biopsyComorbid conditions
1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1980
Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor
McLean R, Siegel N, Kashgarian M. Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor. Nephron 1980, 25: 57-64. PMID: 6986570, DOI: 10.1159/000181754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasement MembraneBiopsyCapillariesChildComplement ActivationComplement C3 Nephritic FactorComplement Inactivator ProteinsComplement Pathway, ClassicalFemaleFluorescent Antibody TechniqueGlomerulonephritisHemolysisHumansImmunoelectrophoresis, Two-DimensionalKidneyLipodystrophyMagnesiumMaleMicroscopy, ElectronConceptsC3 nephritic factorNephritic factorPartial lipodystrophyClassic complement pathwayDense deposit diseaseDense intramembranous depositsRenal diseaseDeposit diseaseIntramembranous depositsPatientsFactor assaysComplement pathwayComplement componentsUltrastructural evidenceCurrent criteriaLipodystrophyDiseaseType IHemolytic assayMCGNAssaysThe significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1974
Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1973
CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE
HAYSLETT J, KASHGARIAN M, BENSCH K, SPARGO B, FREEDMAN L, EPSTEIN F. CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE. Medicine 1973, 52: 93-120. PMID: 4695844, DOI: 10.1097/00005792-197303000-00001.Peer-Reviewed Original ResearchAcute DiseaseAdolescentAdultAgedAutopsyAzathioprineBiopsyChildChild, PreschoolChronic DiseaseFemaleFollow-Up StudiesGlomerulonephritisHumansKidney DiseasesKidney Function TestsMaleMicroscopy, ElectronMiddle AgedNephrosis, LipoidNephrotic SyndromePrednisonePrognosisProteinuriaRemission, SpontaneousSerum AlbuminUrineAn Evaluation of Routine Electron Microscopy in the Examination of Renal Biopsies
Siegel N, Spargo B, Kashgarian M, Hayslett J. An Evaluation of Routine Electron Microscopy in the Examination of Renal Biopsies. Nephron 1973, 10: 209-215. PMID: 4701576, DOI: 10.1159/000180189.Peer-Reviewed Original ResearchConceptsRenal biopsyRoutine electron microscopyConsecutive renal biopsiesUltrastructural studyRenal biopsy materialConsequence of treatmentNatural coursePatient managementBiopsy materialDifferent diagnosesRelevant subclassificationBiopsyRenal pathologistsRoutine casesDiagnosisExaminationLight microscopy
1972
THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS
HAYSLETT J, KASHGARIAN M, COOK C, SPARGO B. THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS. Medicine 1972, 51: 393. PMID: 4115512, DOI: 10.1097/00005792-197209000-00004.Peer-Reviewed Original ResearchCLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1970
A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency
Kotchen T, Knight E, Kashgarian M, Mulrow P. A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency. Nephron 1970, 7: 317-330. PMID: 4316656, DOI: 10.1159/000179832.Peer-Reviewed Original ResearchConceptsRenin activitySevere chronic renal insufficiencyChronic dialysis programRenin substrate levelsChronic renal insufficiencyPlasma renin activityMean arterial pressureRenin-angiotensin systemNormal plasma levelsMalignant hypertensionRenal insufficiencyRenin levelsOnly patientsArterial pressureBlood pressureUremic patientsDialysis programPlasma levelsUremic plasmaAutopsy specimensJG cellsBowie stainPatientsReninDialysis