1987
Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism
JAEGER P, JONES W, KASHGARIAN M, SEGRE G, HAYSLETT J. Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism. European Journal Of Clinical Investigation 1987, 17: 415-420. PMID: 3121345, DOI: 10.1111/j.1365-2362.1987.tb01136.x.Peer-Reviewed Original ResearchConceptsParathyroid hormonePTH infusionChronic hyperparathyroidismPlasma calciumAnimal modelsEffect of PTHProximal HCO3 reabsorptionChronic metabolic acidosisGroups of animalsPrimary hyperparathyroidismAlzet minipumpsSerum calciumTubular reabsorptionAcute studyMetabolic acidosisMetabolic alkalosisRenal handlingTubular acidificationAcid secretionGroup IIHCO3- reabsorptionFree dietHyperparathyroidismCa-free dietNormal levels
1970
Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat
Luke R, Warren Y, Kashgarian M, Levitin H. Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat. Clinical Science 1970, 38: 385-396. PMID: 5442558, DOI: 10.1042/cs0380385.Peer-Reviewed Original ResearchConceptsUrinary net acid excretionNet acid excretionAcid excretionPlasma bicarbonateProximal tubulesBicarbonate absorptionDietary chloride restrictionProximal tubular absorptionUrinary acid excretionEndogenous acid productionLow chloride dietDegree of elevationAcid-base balanceDietary sodiumPlasma chlorideSerum bicarbonateTubular absorptionPhosphate excretionRespiratory acidosisMicropuncture experimentsDepleted ratsHypochloraemiaRatsExcretionRates of sodiumMicropuncture Studies of Chloride and Bicarbonate Absorption in the Proximal Renal Tubule of the Rat in Respiratory Acidosis and in Chloride Depletion
Warren Y, Luke R, Kashgarian M, Levitin H. Micropuncture Studies of Chloride and Bicarbonate Absorption in the Proximal Renal Tubule of the Rat in Respiratory Acidosis and in Chloride Depletion. Clinical Science 1970, 38: 375-383. PMID: 5442557, DOI: 10.1042/cs0380375.Peer-Reviewed Original ResearchConceptsProximal tubulesBicarbonate absorptionRespiratory acidosisMicropuncture studiesPlasma bicarbonateProximal tubular absorptionUrinary acid excretionUrinary chloride excretionLow chloride dietSignificant increaseProximal renal tubulesSodium restrictionHr of exposureTubular absorptionChloride excretionAcid excretionRenal tubulesChloride absorptionHr exposureReciprocal patternDistal sitesTubulesAcidosisExcretionChloride depletion