2000
Regulation of DRA and AE1 in rat colon by dietary Na depletion
Rajendran V, Black J, Ardito T, Sangan P, Alper S, Schweinfest C, Kashgarian M, Binder H. Regulation of DRA and AE1 in rat colon by dietary Na depletion. AJP Gastrointestinal And Liver Physiology 2000, 279: g931-g942. PMID: 11052990, DOI: 10.1152/ajpgi.2000.279.5.g931.Peer-Reviewed Original Research
1999
Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon
Ikuma M, Kashgarian M, Binder H, Rajendran V. Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. American Journal Of Physiology 1999, 276: g539-g549. PMID: 9950829, DOI: 10.1152/ajpgi.1999.276.2.g539.Peer-Reviewed Original ResearchConceptsDietary sodium depletionSodium depletionDistal colonRat colonProtein expressionMRNA abundanceBlot analysisDose-dependent inhibitorApical membrane vesiclesElectroneutral NaCl absorptionWestern blot analysisDifferential regulationNormal ratsProximal colonHOE 694Multiple diverse effectsColonDistal segmentsNaCl absorptionNHE isoformsExchange activityExchanger isoformsNorthern blot analysisDifferential effectsPretranslational level
1998
Role of heat stress response in the tolerance of immature renal tubules to anoxia
Gaudio K, Thulin G, Mann A, Kashgarian M, Siegel N. Role of heat stress response in the tolerance of immature renal tubules to anoxia. American Journal Of Physiology 1998, 274: f1029-f1036. PMID: 9841493, DOI: 10.1152/ajprenal.1998.274.6.f1029.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBlotting, NorthernCarbonyl Cyanide m-Chlorophenyl HydrazoneCell HypoxiaDNA, MitochondrialDNA-Binding ProteinsElectrophoresisHeat Shock Transcription FactorsHeat-Shock ProteinsHot TemperatureHSP72 Heat-Shock ProteinsKidney TubulesMitochondriaNystatinOuabainOxygen ConsumptionRatsRNA, MessengerTranscription Factors
1997
Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion
Sangan P, Rajendran V, Mann A, Kashgarian M, Binder H. Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion. American Journal Of Physiology 1997, 272: c685-c696. PMID: 9124313, DOI: 10.1152/ajpcell.1997.272.2.c685.Peer-Reviewed Original ResearchConceptsDietary K depletionDistal colonNA depletionK-ATPase activityProximal colonLarge intestineRat distal colonActive K absorptionK-ATPaseRenal collecting ductsDietary NaK-ATPase expressionK-ATPase isoformsK depletionRat colonCollecting ductsOuter medullaColonProtein expressionProtein levelsKidneyPolyclonal antibodiesIntestineDuctMRNA
1994
Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia
Van Why S, Mann A, Ardito T, Siegel N, Kashgarian M. Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia. American Journal Of Physiology 1994, 267: f75-f85. PMID: 8048568, DOI: 10.1152/ajprenal.1994.267.1.f75.Peer-Reviewed Original ResearchTransforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase.
Marti H, Lee L, Kashgarian M, Lovett D. Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. American Journal Of Pathology 1994, 144: 82-94. PMID: 8291614, PMCID: PMC1887110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, NorthernCells, CulturedCollagenasesEnzyme-Linked Immunosorbent AssayGlomerular MesangiumHumansImmunohistochemistryMatrix Metalloproteinase 9Molecular ProbesMolecular Sequence DataNephritisRatsRats, WistarTranscription, GeneticTransforming Growth Factor betaConceptsType IV collagenaseHuman mesangial cellsType IVMesangial cellsImmune complex-mediated glomerulonephritisMRNA expressionType IV collagenase mRNA expressionCultured human mesangial cellsCollagenase mRNA expressionMesangial cell synthesisGlomerular inflammatory processesTIMP-1 synthesisNephritic ratsInflammatory processGlomerular matrixMesangial distributionMatrix protein synthesisTIMP-1Direct stimulationTissue inhibitorNormal animalsMesangial compartmentMatrix metalloproteinase synthesisStimulatory effectTIMP-1 inhibitor
1993
Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.
Soifer N, Van Why S, Ganz M, Kashgarian M, Siegel N, Stewart A. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. Journal Of Clinical Investigation 1993, 92: 2850-2857. PMID: 8254039, PMCID: PMC288486, DOI: 10.1172/jci116905.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid IsomerasesAnimalsBlotting, NorthernCarrier ProteinsGene ExpressionImmunohistochemistryIschemiaKidneyKidney GlomerulusKidney TubulesMaleParathyroid Hormone-Related ProteinPeptidylprolyl IsomeraseProtein BiosynthesisProteinsRatsRats, Sprague-DawleyReceptors, Parathyroid HormoneReference ValuesRenal ArteryReperfusionRNA, MessengerConceptsHormone-related proteinMesangial cellsTubular cellsAcute renal ischemic injuryBilateral renal artery occlusionMale Sprague-Dawley ratsParathyroid hormone-related proteinAutocrine/paracrine fashionPTHrP mRNA levelsRenal artery occlusionRenal ischemic injuryMRNA levelsSprague-Dawley ratsDistal tubular cellsSham-operated animalsCyclophilin mRNA levelsProximal tubular cellsLocalization of PTHrPCultured mesangial cellsLocal growth factorsAdult rat kidneyArtery occlusionGlomerular epithelial cellsRenal injuryIschemic injury
1992
Induction and intracellular localization of HSP-72 after renal ischemia
Van Why S, Hildebrandt F, Ardito T, Mann A, Siegel N, Kashgarian M. Induction and intracellular localization of HSP-72 after renal ischemia. American Journal Of Physiology 1992, 263: f769-f775. PMID: 1443167, DOI: 10.1152/ajprenal.1992.263.5.f769.Peer-Reviewed Original ResearchConceptsHSP 72Renal ischemiaHeat shock proteinsIschemic renal injuryMin of reperfusionProtein elaborationHSP mRNA expressionHSP-70 mRNARenal injuryIschemic injuryTransient ischemiaProximal tubulesIschemiaRat kidneyMRNA expressionIntracellular localizationMRNA inductionInjuryTubule morphologyImmunofluorescent localizationShock proteinsVesicular patternCellular recoveryHSP proteinsCellular remodelingExtracellular matrix protein: gene expression and synthesis in cultured rat mesangial cells
ISHIMURA E, STERZEL R, MORII H, KASHGARIAN M. Extracellular matrix protein: gene expression and synthesis in cultured rat mesangial cells. 日本腎臓学会誌 1992, 34: 9-17. PMID: 1593802, DOI: 10.14842/jpnjnephrol1959.34.9.Peer-Reviewed Original ResearchConceptsGene expressionProtein synthesisExtracellular matrixNorthern blottingBasement membrane matrix componentsFetal calf serumCollagen IMesangial cellsMRNA expressionDNA amountSynthesis of ECMCellular confluenceECM productionCultured rat mesangial cellsMatrix componentsRat mesangial cellsExpressionLamininBlottingCellsCalf serumImmunocytochemical studyPrevious immunocytochemical studiesCIIIMRNA