1993
Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy
Hwang S, Harris H, Otuechere G, Yalla S, Sullivan M, Kashgarian M, Benos D, Kleyman T, Zeidel M. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. American Journal Of Physiology 1993, 264: f808-f815. PMID: 8388652, DOI: 10.1152/ajprenal.1993.264.5.f808.Peer-Reviewed Original ResearchConceptsObstructed kidneysIMCD cellsUntreated control kidneysOuabain-insensitive QO2Ouabain-sensitive QO2Urinary obstructionObstructive nephropathyControl kidneysControl animalsControl groupKidneyMonoclonal antibodiesMarked reductionDuct cellsAlpha 1Cellular mechanismsSignificant differencesChannel proteinsReabsorptionAntibodiesOxygen consumption studiesTransport defectRabbitsCellsImmunoblotTransport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1981
Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion
Siegel N, Upadhyaya K, Kashgarian M. Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion. Kidney International 1981, 20: 691-694. PMID: 7334741, DOI: 10.1038/ki.1981.197.Peer-Reviewed Original ResearchConceptsUnilateral ureteral occlusionBilateral ureteral occlusionContralateral kidneyUreteral occlusionRenal functionAdaptive changesCompensatory changesObstructive renal injuryInfusion of indomethacinRelease of obstructionRenal hemodynamicsRenal injuryPattern of recoveryObstructive nephropathyPathophysiologic alterationsRenal massesUnoperated kidneysKidneyOcclusionAdaptive alterationsHemodynamicsControl organsIndomethacinAlterationsPresent study
1980
Renal perfusion and intratubular pressure during ureteral occlusion in the rat
Gaudio K, Siegel N, Hayslett J, Kashgarian M. Renal perfusion and intratubular pressure during ureteral occlusion in the rat. American Journal Of Physiology 1980, 238: f205-f209. PMID: 7369362, DOI: 10.1152/ajprenal.1980.238.3.f205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBody WeightHydrostatic PressureKidneyKidney Tubules, ProximalMalePressureRatsRegional Blood FlowTime FactorsUreteral ObstructionConceptsTotal renal blood flowBilateral ureteral occlusionBody wt-1Tubular hydrostatic pressureUreteral occlusionKidney 1WT-1Renal blood flowRenal hemodynamicsRenal perfusionIntratubular pressureBlood flowControl animalsSustained increasePeak riseOcclusionMmHgIndomethacinSubsequent time intervalsRatsPatterns of changeAlterationsAnimalsPrimary roleSubsequent time periods
1977
Renal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Urea NitrogenDiuresisGlomerular Filtration RateIschemiaKidney CortexMaleRatsRegional Blood FlowTime FactorsUreteral ObstructionConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy
1974
Intrarenal hemodynamics in postobstructive diuresis.
Feldman R, Siegel N, Kashgarian M, Hayslett J, Lytton B. Intrarenal hemodynamics in postobstructive diuresis. Journal Of Urology 1974, 12: 172-5. PMID: 4443183.Peer-Reviewed Original Research