1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1974
Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum