1994
The benefit of early treatment with immunosuppressive agents in lupus nephritis.
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The benefit of early treatment with immunosuppressive agents in lupus nephritis. The Journal Of Rheumatology 1994, 21: 2046-51. PMID: 7869308.Peer-Reviewed Original ResearchConceptsHour urinary protein excretionUrinary protein excretionLead-time biasRenal biopsyLupus nephritisRenal insufficiencyRenal involvementSerum creatinineProtein excretionImmunosuppressive agentsEarly treatmentHigh-dose prednisoneLupus renal involvementSubsequent renal insufficiencyTime biasFirst renal biopsySelection biasDose prednisoneTubulointerstitial indexRenal diseaseLongterm prognosisImmunosuppressive drugsEffect of durationBiopsySignificant association
1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern
1982
Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.
Sterzel R, Ehrich J, Lucia H, Thomson D, Kashgarian M. Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats. Laboratory Investigation 1982, 46: 209-14. PMID: 7038293.Peer-Reviewed Original ResearchConceptsGlomerular immune depositsImmune depositsElectron-dense depositsDay 10Day 20Young Sprague-Dawley ratsRenal functional damageUrinary protein excretionInfiltration of monocytesGlomerular cell countSprague-Dawley ratsEsterase-positive monocytesGlomerular basement membraneAcute malariaProtein excretionGlomerular injuryMesangial distributionSerum urea valuesDay 100Granular depositionImmune complexesFunctional damageNormal rangeMesangial matrixCell count
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index