Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy
Hwang S, Harris H, Otuechere G, Yalla S, Sullivan M, Kashgarian M, Benos D, Kleyman T, Zeidel M. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. American Journal Of Physiology 1993, 264: f808-f815. PMID: 8388652, DOI: 10.1152/ajprenal.1993.264.5.f808.Peer-Reviewed Original ResearchConceptsObstructed kidneysIMCD cellsUntreated control kidneysOuabain-insensitive QO2Ouabain-sensitive QO2Urinary obstructionObstructive nephropathyControl kidneysControl animalsControl groupKidneyMonoclonal antibodiesMarked reductionDuct cellsAlpha 1Cellular mechanismsSignificant differencesChannel proteinsReabsorptionAntibodiesOxygen consumption studiesTransport defectRabbitsCellsImmunoblotTransport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction