2022
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine model
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patientsPredictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy
ESDAILE J, FEDERGREEN W, QUINTAL H, SUISSA S, HAYSLETT J, KASHGARIAN M. Predictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy. QJM 1991, 81: 907-918. DOI: 10.1093/oxfordjournals.qjmed.a068639.Peer-Reviewed Original ResearchLupus nephritisRenal biopsySerum creatinineClinical prediction modelBiopsy variablesPrognosis of lupus nephritisDiffuse proliferative lupus nephritisProliferative lupus nephritisDiffuse proliferative nephritisTime of biopsySubepithelial electron-dense depositsActivity index scoreShort-term prognosisBiopsy informationLaboratory predictorsPlatelet countRenal injuryTubulointerstitial scoresProliferative nephritisUnivariate analysisElectron-dense depositsBiopsyCoexisting illnessesNephritisUrinary protein
1976
Kidney transplant biopsies in the diagnosis and management of acute rejection reactions
Finkelstein F, Siegel N, Bastl C, Forrest J, Kashgarian M. Kidney transplant biopsies in the diagnosis and management of acute rejection reactions. Kidney International 1976, 10: 171-178. PMID: 787617, DOI: 10.1038/ki.1976.92.Peer-Reviewed Original ResearchConceptsAcute clinical rejectionTime of biopsyClinical rejectionAcute rejectionTransplant biopsiesGraft recipientsClinical statusRejection reactionAcute rejection reactionGlomerular endothelial swellingStandard immunosuppressive treatmentInstitution of treatmentKidney transplant biopsiesRenal transplant biopsiesHistopathologic categorizationImmunosuppressive treatmentClinical responseRenal functionEndothelial swellingHistologic featuresEndothelial edemaHistopathologic changesInterstitial edemaClinical dataRetrospective analysis