1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern
1982
The mesangium and glomerulonephritis
Sterzel R, Lovett D, Stein H, Kashgarian M. The mesangium and glomerulonephritis. Journal Of Molecular Medicine 1982, 60: 1077-1094. PMID: 7144055, DOI: 10.1007/bf01715838.Peer-Reviewed Original ResearchConceptsGlomerular diseaseImmune competent cellsProgressive glomerular sclerosisExperimental glomerular diseaseMesangial cell proliferationMesangial spacePeripheral capillary wallsCertain glomerular diseasesLocal hemodynamic factorsIntrinsic mesangial cellsGlomerular basement membraneMesangial dysfunctionGlomerular sclerosisInflammatory cellsGlomerular hypertensionHistopathologic studyMarked proteinuriaGlomerular disordersSubendothelial depositsPericapillary tissueTherapeutic approachesImmune complexesFunctional damageMesangial abnormalitiesCapillary pericytes
1980
The significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1977
THE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS
Domoto D, Siegel N, Kashgarian M. THE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS. Pediatric Research 1977, 11: 549-549. DOI: 10.1203/00006450-197704000-01075.Peer-Reviewed Original ResearchSEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN)
Siegel N, Kashgarian M. SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN). Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01126.Peer-Reviewed Original ResearchInterstitial fibrosisMesangial sclerosisSubendothelial depositsSecond renal biopsyDiffuse mesangial proliferationHistologic improvementSteroid therapyImmunosuppressive agentsRenal biopsyInitial diagnosisMesangial proliferationPatientsSubepithelial depositsSequential histologicSclerosisBasement membraneFibrosisRecent dataSignificant changesProliferationProgressive changesGlomerulonephritisBiopsyHistologicTherapy