1994
The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictors
1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern
1992
Can Experienced Clinicians Predict the Outcome of Lupus Nephritis?
Esdaile J, Mackenzie T, Barré P, Danoff D, Kirk Osterland C, Somerville P, Quintal H, Kashgarian M, Suissa S. Can Experienced Clinicians Predict the Outcome of Lupus Nephritis? Lupus 1992, 1: 205-214. PMID: 1301984, DOI: 10.1177/096120339200100403.Peer-Reviewed Original Research
1988
Beneficial effect of thyroxin in the treatment of ischemic acute renal failure
Sutter P, Thulin G, Stromski M, Ardito T, Gaudio K, Kashgarian M, Siegel N. Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatric Nephrology 1988, 2: 1-7. PMID: 2856365, DOI: 10.1007/bf00870370.Peer-Reviewed Original ResearchConceptsAcute renal failureIschemic acute renal failureRenal failureIschemic controlsNormal salineSaline-treated ischemic controlsBeneficial effectsBetter kidney functionDose of T4Min of reflowT4-treated ratsEffect of thyroxinRenal functionKidney functionNS animalsRenal ischemiaInulin clearanceSaline controlsDay 3Day 7IschemiaT4 animalsRenal ATPCellular mechanismsSignificant increase
1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENa
1981
Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion
Siegel N, Upadhyaya K, Kashgarian M. Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion. Kidney International 1981, 20: 691-694. PMID: 7334741, DOI: 10.1038/ki.1981.197.Peer-Reviewed Original ResearchConceptsUnilateral ureteral occlusionBilateral ureteral occlusionContralateral kidneyUreteral occlusionRenal functionAdaptive changesCompensatory changesObstructive renal injuryInfusion of indomethacinRelease of obstructionRenal hemodynamicsRenal injuryPattern of recoveryObstructive nephropathyPathophysiologic alterationsRenal massesUnoperated kidneysKidneyOcclusionAdaptive alterationsHemodynamicsControl organsIndomethacinAlterationsPresent study
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increaseTHE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS
Domoto D, Siegel N, Kashgarian M. THE SIGNIFICANCE OF ELECTRON DENSE DEPOSITS IN MILD LUPUS NEPHRITIS. Pediatric Research 1977, 11: 549-549. DOI: 10.1203/00006450-197704000-01075.Peer-Reviewed Original Research
1976
Kidney transplant biopsies in the diagnosis and management of acute rejection reactions
Finkelstein F, Siegel N, Bastl C, Forrest J, Kashgarian M. Kidney transplant biopsies in the diagnosis and management of acute rejection reactions. Kidney International 1976, 10: 171-178. PMID: 787617, DOI: 10.1038/ki.1976.92.Peer-Reviewed Original ResearchConceptsAcute clinical rejectionTime of biopsyClinical rejectionAcute rejectionTransplant biopsiesGraft recipientsClinical statusRejection reactionAcute rejection reactionGlomerular endothelial swellingStandard immunosuppressive treatmentInstitution of treatmentKidney transplant biopsiesRenal transplant biopsiesHistopathologic categorizationImmunosuppressive treatmentClinical responseRenal functionEndothelial swellingHistologic featuresEndothelial edemaHistopathologic changesInterstitial edemaClinical dataRetrospective analysis
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index