2022
Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice
Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A. Podocyte VEGF-A Knockdown Induces Diffuse Glomerulosclerosis in Diabetic and in eNOS Knockout Mice. Frontiers In Pharmacology 2022, 12: 788886. PMID: 35280251, PMCID: PMC8906751, DOI: 10.3389/fphar.2021.788886.Peer-Reviewed Original ResearchDiabetic kidney diseaseGlomerular filtration rateDiffuse glomerulosclerosisDiabetic miceRenal failureNitric oxideMassive proteinuriaKnockout miceEndothelial nitric oxide synthase knockout miceNitric oxide synthase knockout miceNormal glomerular filtration rateAbsence of diabetesENOS knockout miceSynthase knockout miceVascular endothelial growth factorTargetable molecular mechanismsFoot process effacementEndothelial growth factorAbnormal S-nitrosylationArteriolar hyalinosisGFR lossMild proteinuriaSevere proteinuriaKidney diseaseUrinary excretion
1998
Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Perazella M, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clinical Nephrology 1998, 50: 194-6. PMID: 9776425.Peer-Reviewed Original ResearchConceptsRenal biopsy findingsRenal insufficiencyBiopsy findingsMild renal insufficiencyAcute renal failureIndinavir crystalsIndinavir therapyRenal failureAntiretroviral agentsUrinary obstructionAIDS patientsCellular castsPatientsPyuriaInsufficiencyRecent reportsSmall percentDiscontinuationNephropathyMedicationsSecond caseDiuresisNephrolithiasisIndinavirObstruction
1995
Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis
Ishimura E, Nishizawa Y, Shoji S, Okumura M, Nishitani H, Kim C, Watanabe Y, Wakasa K, Morii H, Kashgarian M. Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis. American Journal Of Kidney Diseases 1995, 26: 654-657. PMID: 7573022, DOI: 10.1016/0272-6386(95)90604-5.Peer-Reviewed Original ResearchConceptsEnd-stage renal failureMonoclonal IgG-kappaType I cryoglobulinemiaOnset of diseaseElectron-dense depositsEssential cryoglobulinemiaRenal failureClinical courseRenal biopsyNephrotic syndromeIgG kappaLower extremitiesCryoglobulinsGelatinous appearanceGlomerular capillariesCryoglobulinemiaGlomerulonephritisInitial onsetBiopsyDiseaseOnsetYears
1994
The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictorsA granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8.
Ziesche R, Roth M, Papakonstantinou E, Nauck M, Hörl W, Kashgarian M, Block L. A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 301-305. PMID: 8278382, PMCID: PMC42935, DOI: 10.1073/pnas.91.1.301.Peer-Reviewed Original ResearchConceptsGranulocyte inhibitory proteinsInterleukin-6Chronic renal diseaseChronic renal failureProgression of glomerulosclerosisHuman mesangial cellsInhibitory proteinPluripotential effectsRenal failureRenal diseaseCytokine expressionIL-6IL-8Interleukin-8Inflammatory reactionGIP resultsGlomerular responseMesangial cellsC-jun mRNAC-fos geneC-JunDe novo synthesisNovo synthesisExpressionOverall effect
1989
The Clinical and Renal Biopsy Predictors of Long-term Outcome in Lupus Nephritis: A Study of 87 Patients and Review of the Literature
ESDAILE J, LEVINTON C, FEDERGREEN W, HAYSLETT J, KASHGARIAN M. The Clinical and Renal Biopsy Predictors of Long-term Outcome in Lupus Nephritis: A Study of 87 Patients and Review of the Literature. QJM 1989, 72: 779-833. DOI: 10.1093/oxfordjournals.qjmed.a068371.Peer-Reviewed Original ResearchDuration of renal diseasePresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseRenal insufficiencyRenal failurePrognostic markerClinical modelMarker of immunological activityRenal systemic lupus erythematosusPredictor of long-term outcomeMarkers of disease severityUrinary excretion of proteinNon-renal SLEImmunologic disease activitySystemic lupus erythematosusPredictors of fatalityExcretion of proteinRenal severityConsecutive patientsRenal outcomesChronicity indexBiopsy variablesSerum creatinineThe clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature.
Esdaile J, Levinton C, Federgreen W, Hayslett J, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM 1989, 72: 779-833. PMID: 2694209.Peer-Reviewed Original ResearchConceptsPresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseClinical modelRenal insufficiencyRenal failurePrognostic markerRelevant long-term outcomesRenal systemic lupus erythematosusImmunologic disease activityNon-renal SLESystemic lupus erythematosusImportant prognostic markerChronicity indexRenal outcomesRenal severityDisease activityNew predictive informationSerum creatinineConsecutive patientsLupus erythematosusPrognostic factorsRenal biopsyComorbid conditions
1988
Beneficial effect of thyroxin in the treatment of ischemic acute renal failure
Sutter P, Thulin G, Stromski M, Ardito T, Gaudio K, Kashgarian M, Siegel N. Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatric Nephrology 1988, 2: 1-7. PMID: 2856365, DOI: 10.1007/bf00870370.Peer-Reviewed Original ResearchConceptsAcute renal failureIschemic acute renal failureRenal failureIschemic controlsNormal salineSaline-treated ischemic controlsBeneficial effectsBetter kidney functionDose of T4Min of reflowT4-treated ratsEffect of thyroxinRenal functionKidney functionNS animalsRenal ischemiaInulin clearanceSaline controlsDay 3Day 7IschemiaT4 animalsRenal ATPCellular mechanismsSignificant increase
1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENaHEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2
Gaudio K, Thulin G, Kashgarian M, Siegel N. HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2. Pediatric Research 1984, 18: 362-362. DOI: 10.1203/00006450-198404001-01613.Peer-Reviewed Original ResearchRenal blood flowHemodynamic effectsATP-MgCl2Normal salineBlood flowInitial hemodynamic effectsAcute renal failureInfusion of dopamineRenal failureRenal ischemiaPostischemic infusionInulin clearanceVasoactive compoundsTubular cellsSalutary effectsCINInfusionHrDopamineCellular metabolismIschemiaInjuryRatsSalineClearance
1980
Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats
Siegel N, Glazier W, Chaudry I, Gaudio K, Lytton B, Baue A, Kashgarian M. Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney International 1980, 17: 338-349. PMID: 7401453, DOI: 10.1038/ki.1980.39.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal injuryRenal failureAcute renal injuryIschemic renal injuryAdenine nucleotidesFocal cellular necrosisElevated FENaRenal insultIschemic kidneyIschemic periodTubular functionAcute insultNonischemic kidneysPostischemic infusionFunctional impairmentTubular cellsDegree of improvementCellular necrosisRatsInfusionCINUltrastructural changesUltrastructural studyFENaThe importance of nonrenal involvement in hemolytic-uremic syndrome.
Upadhyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel N. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics 1980, 65: 115-20. PMID: 7355005, DOI: 10.1542/peds.65.1.115.Peer-Reviewed Original Research
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increase
1976
Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure.
Kashgarian M, Siegel N, Ries A, DiMeola H, Hayslett J. Hemodynamic aspects in development and recovery phases of experimental postischemic acute renal failure. Kidney International Supplement 1976, 6: s160-8. PMID: 1068320.Peer-Reviewed Original ResearchConceptsPostischemic acute renal failureAcute renal failureRenal failureHemodynamic aspectsRecovery phase
1974
Clinical spectrum of postpartum renal failure
Finkelstein F, Kashgarian M, Hayslett J. Clinical spectrum of postpartum renal failure. The American Journal Of Medicine 1974, 57: 649-654. PMID: 4432867, DOI: 10.1016/0002-9343(74)90019-9.Peer-Reviewed Original ResearchConceptsPostpartum renal failureRenal failureFibrin depositionExtensive fibrin depositionFulminant renal failureMinor renal dysfunctionRenal functional abnormalitiesSpectrum of diseaseRenal dysfunctionFatal courseClinical spectrumPostpartum periodRenal abnormalitiesRenal vasculatureFunctional abnormalitiesPatientsAbnormalitiesFailureDysfunctionDiseaseVasculature
1971
Effect of azathioprine in patients with lupus glomerulonephritis
Hayslett J, Cook C, Kashgarian M, Spargo B. Effect of azathioprine in patients with lupus glomerulonephritis. Pediatric Research 1971, 5: 384-385. DOI: 10.1203/00006450-197108000-00058.Peer-Reviewed Original ResearchSevere glomerulonephritisRenal failureLupus glomerulonephritisNephrotic syndromeRenal lesionsMonths of therapyEvidence of progressionSevere renal failureMonths of treatmentEffect of azathioprinePatient's proteinuriaMembranous nephropathySevere nephritisHistological featuresIntensive treatmentMembranous changesGlomerulonephritisInexorable progressionProliferative lesionsPatientsLow dosesLesionsStriking decreaseAzathioprineMonthsSuccessful Treatment of Renal Failure in Goodpasture's Syndrome
Hayslett J, Berte J, Kashgarian M. Successful Treatment of Renal Failure in Goodpasture's Syndrome. JAMA Internal Medicine 1971, 127: 953-957. PMID: 5560872, DOI: 10.1001/archinte.1971.00310170161025.Peer-Reviewed Original ResearchConceptsGoodpasture's syndromeRenal failureYale-New Haven HospitalEvaluation of hemoptysisSymptoms of bronchospasmFurther renal deteriorationGlomerular basement membraneAcute bronchitisRenal deteriorationRenal insufficiencyPulmonary functionPulmonary tuberculosisSuccessful treatmentRapid progressionProlonged survivalImmune responseSerial studiesSyndromeWhite womenHemoptysisRecent evidenceBasement membraneComplete restorationWomenBronchospasm
1969
Progression of Lipoid Nephrosis to Renal Insufficiency
Hayslett J, Krassner L, Bensch K, Kashgarian M, Epstein F. Progression of Lipoid Nephrosis to Renal Insufficiency. New England Journal Of Medicine 1969, 281: 181-187. PMID: 5790494, DOI: 10.1056/nejm196907242810402.Peer-Reviewed Original ResearchMechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats