1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissue
1969
Mechanism of change in the excretion of sodium per nephron when renal mass is reduced
Hayslett J, Kashgarian M, Epstein F. Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. Journal Of Clinical Investigation 1969, 48: 1002-1006. PMID: 5771184, PMCID: PMC322314, DOI: 10.1172/jci106056.Peer-Reviewed Original ResearchConceptsSodium excretionRenal tissueProximal tubular absorptionExcretion of sodiumHealthy nephronsPopulation of nephronsRenal insufficiencyRenal ablationRenal failureTubular absorptionRenal massesSodium balanceGlomerular filtrationDistal tubulesExcretionNephronOsmotic loadEarly adjustmentStepwise increaseMechanisms of changeTissueUninephrectomyHyperfiltrationInsufficiencyRats