1995
Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis
Ishimura E, Nishizawa Y, Shoji S, Okumura M, Nishitani H, Kim C, Watanabe Y, Wakasa K, Morii H, Kashgarian M. Heat-insoluble cryoglobulin in a patient with essential type I cryoglobulinemia and massive cryoglobulin-occlusive glomerulonephritis. American Journal Of Kidney Diseases 1995, 26: 654-657. PMID: 7573022, DOI: 10.1016/0272-6386(95)90604-5.Peer-Reviewed Original ResearchConceptsEnd-stage renal failureMonoclonal IgG-kappaType I cryoglobulinemiaOnset of diseaseElectron-dense depositsEssential cryoglobulinemiaRenal failureClinical courseRenal biopsyNephrotic syndromeIgG kappaLower extremitiesCryoglobulinsGelatinous appearanceGlomerular capillariesCryoglobulinemiaGlomerulonephritisInitial onsetBiopsyDiseaseOnsetYears
1986
A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia
Seney F, Federgreen W, Stein H, Kashgarian M. A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia. JAMA Internal Medicine 1986, 146: 137-141. PMID: 3942445, DOI: 10.1001/archinte.1986.00360130167023.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNephrotic syndromeLymphocytic leukemiaNephrotic Syndrome AssociatedCommon glomerular lesionImmune complex diseaseRenal diseaseMembranoproliferative glomerulonephritisCellular immunitySyndrome AssociatedGlomerular lesionsImmunoglobulin productionPatientsAvailable evidenceSyndromeLeukemiaDiseaseGlomerulonephritisLesionsImmunity
1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroids
1974
CYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME
Siegel N, Gur A, Krassner L, Kashgarian M, Cook C. CYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME. Pediatric Research 1974, 8: 461-461. DOI: 10.1203/00006450-197404000-00724.Peer-Reviewed Original ResearchNephrotic syndromeComplete remissionSteroid-resistant minimal change nephrotic syndromeMinimal change nephrotic syndromeSteroid-resistant nephrotic syndromeCourses of cyclophosphamideMinimal change lesionChange nephrotic syndromeTreatment of childrenSteroid therapyGonadal toxicityInitial treatmentSuch therapyCyclophosphamideWeek courseSyndromeLittle dataPrednisoneRemissionTreatmentPatientsChildrenTherapyGlucosteroidsRelapseMinimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum
1971
Effect of azathioprine in patients with lupus glomerulonephritis
Hayslett J, Cook C, Kashgarian M, Spargo B. Effect of azathioprine in patients with lupus glomerulonephritis. Pediatric Research 1971, 5: 384-385. DOI: 10.1203/00006450-197108000-00058.Peer-Reviewed Original ResearchSevere glomerulonephritisRenal failureLupus glomerulonephritisNephrotic syndromeRenal lesionsMonths of therapyEvidence of progressionSevere renal failureMonths of treatmentEffect of azathioprinePatient's proteinuriaMembranous nephropathySevere nephritisHistological featuresIntensive treatmentMembranous changesGlomerulonephritisInexorable progressionProliferative lesionsPatientsLow dosesLesionsStriking decreaseAzathioprineMonths